whats the longest anyone has stayed on one dose
lot-log.csv
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#dosing-titration 2025-03-05
Wednesday44 messages10 participantstimes are UTC
Highlights from this day
- seven_five_sweet — if you are going up because the scale stalled for two weeks, wait. two weeks is noise 13:49
- no_appetite_nia — if it "stopped working after four days" that is almost never pharmacokinetics 15:14
- noct.titrate — is there a trial anywhere that studied twice weekly, or is it all anecdote 16:11
- third_shift — how do you decide between holding and stepping when both feel wrong 16:29
- brisbane_bac — i escalate on symptoms. if the current dose is still doing something i stay on it 17:14
whats your rule for when a side effect means hold rather than push
ok so do you count from injection day or from when you actually felt it
end of week thing
go slower
i went up too fast and im paying for it, do i drop back or ride it out
anyone here split their weekly into two and would they do it again
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if you are going up because the scale stalled for two weeks, wait. two weeks is noise
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not advice
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small steps are better than big ones and the only reason people take big ones is impatience, ymmv
the honest answer is that most of us are running protocols nobody has ever studied
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*VendorInvestigate not the other one
if you are asking whether to go up, the fact you are asking usually means not yet, happy to be corrected
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update question: did anyone who held for 3 months regret it
appetite returning at the end of the week is extremely common and is not the dose failing
weights-monthly.csv
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if the current dose is still working, going up is spending headroom you might want later
coming back to this coming down from 1.7 to 1, how bad is the appetite rebound
my dose day has drifted 8 days later over 26 months, does it matter
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, happy to be corrected
do you tell your prescriber you held or do you just hold
if it "stopped working after four days" that is almost never pharmacokinetics
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while im here i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
i went from 1.7 to 7.5 and honestly could not tell the difference in appetite
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
hold
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)whats the smallest step anyone has managed between doses
coa-a-2418.pdf
1 page · 756 KB · not retained in the public archive
my titration ladder took 4 months to climb and i would do it slower again
came down, no regrets
is there a trial anywhere that studied twice weekly, or is it all anecdote
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
anyone tracked whether a smaller more frequent dose changed their side effects
holding is not failing. most people here who lasted two years held at least one dose for months
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, take that with a pinch of salt
how do you decide between holding and stepping when both feel wrong
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split dosing has no trial behind it. people here do it and report on it, thats all
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
coming back to this how do you tell a plateau from just being at your set point
i escalate on symptoms. if the current dose is still doing something i stay on it
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is week 27 too early to be thinking about the next step
if i hold at 2.4 indefinitely am i losing anything
stepping back down on purpose is a completely reasonable move and this channel should say so more often, n of 1 obviously
[edited]thats anecdote
holding is not failing. most people here who lasted two years held at least one dose for months
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
i drifted from sunday to wednesday over a year and only noticed when i checked the log