#dosing-titration 2025-03-03

Monday20 messages6 participantstimes are UTC

Highlights from this day

week_three_wall — i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else 21:36
week_three_wall — follow up if i hold at 15 indefinitely am i losing anything 21:51
cold_chain_cmdr — i have been at 5 for 9 months and honestly i have stopped wanting to move 22:25
luerlok — if the current dose is still working, going up is spending headroom you might want later 22:28
vial_ledger — quick one the trials escalated on a fixed schedule because a trial has to. you are not a trial 23:00

end of week thing

update question: did anyone who held for 6 months regret it

i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else

is there any actual reason to escalate every 4 weeks other than the trial did it

i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat

half life is a week

two weeks is nothing

❤️1🙏13

follow up if i hold at 15 indefinitely am i losing anything

🤝7

n of 1

my titration ladder took 8 months to climb and i would do it slower again

too early imo

not advice

dose day drift is mostly harmless with a weekly compound, but pick a day and defend it

is it normal for appetite to come back at the end of the week

i have been at 5 for 9 months and honestly i have stopped wanting to move

wk 1-4    2.5mg
wk 5-8    5.0mg
wk 9-20   7.5mg   <- stayed here
wk 21-24  10.0mg  (no extra benefit for me)
wk 25+    7.5mg   (came back down)

👀16❤️11

with a roughly seven day half-life you are near steady state after about five weeks at a dose

if the current dose is still working, going up is spending headroom you might want later

thats anecdote

quick one the trials escalated on a fixed schedule because a trial has to. you are not a trial

unrelated but if i took it 7 days late do i shift the schedule or go back to the old day