held for months
#dosing-titration 2025-03-07
Friday49 messages11 participantstimes are UTC
Highlights from this day
- mg_per_ml — stepping back down on purpose is a completely reasonable move and this channel should say so more often 21:36
- taper_tess — the honest answer is that most of us are running protocols nobody has ever studied 21:44
- taper_tess — i drifted from sunday to wednesday over a year and only noticed when i checked the log 21:59
- taper_tess — i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else 22:06
- mg_per_ml — plateau versus set point is not answerable in under six months of data 22:19
if the current dose is still working, going up is spending headroom you might want later
slightly off topic but coming down from 12 to 10, how bad is the appetite rebound
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
the ladder in the trials is a starting point, not a schedule you owe anyone, thats one data point
stepping back down on purpose is a completely reasonable move and this channel should say so more often
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the trials escalated on a fixed schedule because a trial has to. you are not a trial
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small steps are better than big ones and the only reason people take big ones is impatience
hold
the honest answer is that most of us are running protocols nobody has ever studied
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i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
i hold for two months minimum before i decide a dose has stopped doing anything
if it "stopped working after four days" that is almost never pharmacokinetics
no trial for that
genuine question if you are asking whether to go up, the fact you are asking usually means not yet
thats noise
genuine question i went from 2.4 to 0.5 and honestly could not tell the difference in appetite, not advice obviously
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half life is a week
i drifted from sunday to wednesday over a year and only noticed when i checked the log
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is week 13 too early to be thinking about the next step
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two weeks is nothing
appetite returning at the end of the week is extremely common and is not the dose failing
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
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my titration ladder took 25 months to climb and i would do it slower again, not advice obviously
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split dosing has no trial behind it. people here do it and report on it, thats all
has anyone gone up and then straight back down and been glad they tried
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
plateau versus set point is not answerable in under six months of data
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whats the smallest step anyone has managed between doses
i would hold
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if you are going up because the scale stalled for two weeks, wait. two weeks is noise, we shall see
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dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
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my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
i escalate on symptoms. if the current dose is still doing something i stay on it
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is there a trial anywhere that studied twice weekly, or is it all anecdote
how do you tell a plateau from just being at your set point
came down, no regrets
ok so the people who do best here are almost always the ones going slowest
ok so i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
i went up too fast and im paying for it, do i drop back or ride it out
steady state is 5 weeks
thats normal
with a roughly seven day half-life you are near steady state after about five weeks at a dose
came down from a treatment dose to maintenance over about three months and it was uneventful
not advice, i think
thats anecdote
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
[edited]pick a day and stick to it, i have it written down somewhere