has REDEFINE reported or are people quoting earlier work
#cagrilintide 2026-06-23
Tuesday40 messages9 participantstimes are UTC
Highlights from this day
- pioneer_pia — dropped the GLP-1 and stayed on this alone for 18 months, appetite held but weight barely moved the slower titration in here is community habit as much as anything,… 15:45
- rotterdam_recon — how many weeks before you noticed anything on monotherapy 17:03
- first_and_last_four — update on the earlier thing amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist 17:52
- first_and_last_four — CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it 17:53
- split_shipment — back after 2 months, is monotherapy still a minority thing here 20:49
noticed something around week 3 on monotherapy, well after i had given up expecting to
i was sceptical about monotherapy and after 24 months im still sceptical, just less so
cant separate them
dropped the GLP-1 and stayed on this alone for 18 months, appetite held but weight barely moved
the slower titration in here is community habit as much as anything, the trials had their own schedule
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i titrated over twice as many weeks as i did on semaglutide and that was right for me
monotherapy question, did appetite move for you without a GLP-1 alongside
monotherapy did work for me, just slower and smaller than i expected
amylin not glp-1
fullness rather than nausea
did anyone find monotherapy underwhelming
how slow are people titrating this compared to cagrilintide
coming back to this the fullness thing is the part people describe differently, food stops being interesting rather than repellent
the nausea felt different rather than less, more fullness and less of the queasy wave
the slower titration in here is community habit as much as anything, the trials had their own schedule
weekly for me, same day every week, no reason beyond habit, i have it written down somewhere
cagrisema thats it
is the weekly schedule the same here
is 2.4 the number for this too or am i confusing compounds
the slower titration in here is community habit as much as anything, the trials had their own schedule
how many weeks before you noticed anything on monotherapy
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held at 0.25 for 3 months on monotherapy before i touched it again
whats REDEFINE testing exactly
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
two Medutest results on the same QST lot came back 97.4 and 99, closer than i expected
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monotherapy was underwhelming for me and i say that as someone who wanted it to work
[edited]lost 54lb over 8 months on the combination and i genuinely cannot apportion it, we shall see
update on the earlier thing amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
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CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
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changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
combination GI was worse than either alone for me, which is not what i had read anywhere
[edited]i keep the two on separate days so if something goes wrong i have a chance of knowing which
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went slower because the first step gave me two rough days and i took that as information
$72 for a 20 vial and it lasts me longer than the GLP-1 does at my doses
2 in 0.5ml gives 2mg/ml which is what i use, purely because the units come out round
titrating dead slow
whats the recon people use, 15 in 2ml
*Janoshik not the other one
underwhelming honestly
back after 2 months, is monotherapy still a minority thing here
dosing them on different days made no difference i could detect