different not less
#cagrilintide 2026-06-21
Sunday54 messages11 participantstimes are UTC
Highlights from this day
- belfast_bac — does the fullness effect fade the way appetite suppression does weekly for me, same day every week, no reason beyond habit 21:29
- pioneer_pia — REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work, ymmv 22:47
- peak_split — the reason nausea reads differently is timing, mine arrived on the second day rather than the first 23:10
whats the recon people use, 20 in 3ml
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
combination for me
titrating dead slow
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monotherapy did work for me, just slower and smaller than i expected
15 in 2.5ml gives 5mg/ml which is what i use, purely because the units come out round
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
whats REDEFINE testing exactly
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cant separate them
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amylin not glp-1
quick one the slower titration in here is community habit as much as anything, the trials had their own schedule
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quick one anyone stopped the GLP-1 and kept only this
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REDEFINE is the trial
thats the phase 3 one
anyone holding at 0.25 for a while before stepping
10 in 2ml gives 4mg/ml which is what i use, purely because the units come out round
underwhelming honestly
the nausea felt different rather than less, more fullness and less of the queasy wave
right so added it to an existing tirzepatide dose rather than starting both, which made attribution possible
did the nausea feel different to you or just less
£120 for a 2 vial and it lasts me longer than the GLP-1 does at my doses
does amylin do something about fullness that the GLP-1 doesnt
On this day 5 years ago this channel logged 96 messages.
monotherapy question, did appetite move for you without a GLP-1 alongside
slightly off topic but the fullness thing is the part people describe differently, food stops being interesting rather than repellent
does the fullness effect fade the way appetite suppression does
weekly for me, same day every week, no reason beyond habit
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i was sceptical about monotherapy and after 21 months im still sceptical, just less so
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if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
two Janoshik results on the same JEEP lot came back 99 and 99.4, closer than i expected
noticed something around week 28 on monotherapy, well after i had given up expecting to
held mine a while
monotherapy was underwhelming for me and i say that as someone who wanted it to work
cagrisema thats it
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
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is there a reason people titrate this over more weeks than the others
did the combination change your GI compared to the GLP-1 alone
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monotherapy here
did anyone add this to an existing tirzepatide dose rather than starting both
genuine question is the weekly schedule the same here
dosing them on different days made no difference i could detect
went slower because the first step gave me two rough days and i took that as information
stopped for 17 months and the fullness went within a fortnight of the last dose
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back after 6 months, is monotherapy still a minority thing here
right so nobody should copy my schedule, im describing it because people asked what a slow ramp looks like, anyway
is the nausea profile genuinely different or am i imagining it
slower than the others
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work, ymmv
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separate days
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
slightly off topic but how many weeks before you noticed anything on monotherapy
you cannot tell which of the two is doing what in a combination and i stopped pretending i could, still working it out
i keep the two on separate days so if something goes wrong i have a chance of knowing which
combination GI was worse than either alone for me, which is not what i had read anywhere
the reason nausea reads differently is timing, mine arrived on the second day rather than the first
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amylin analogue, so its not a GLP-1 at all right