REDEFINE is the trial
#cagrilintide 2026-05-21
Thursday44 messages10 participantstimes are UTC
Highlights from this day
- marrow.mod — does the fullness effect fade the way appetite suppression does 17:34
- gus_charts — two VendorInvestigate results on the same SSA lot came back 96.8 and 99, closer than i expected 18:11
- VialBot — Verification log updated: MKM — evidence added, status unchanged. 18:19
- gus_charts — how many weeks before you noticed anything on monotherapy 18:45
slightly off topic but whats REDEFINE testing exactly
stopped for 7 months and the fullness went within a fortnight of the last dose
held mine a while
👀7😂3
unrelated but REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work, not advice obviously
genuine question CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
amylin analogue, so its not a GLP-1 at all right
the slower titration in here is community habit as much as anything, the trials had their own schedule
cant separate them
follow up how slow are people titrating this compared to tirzepatide
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
has REDEFINE reported or are people quoting earlier work
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
is 2.4 the number for this too or am i confusing compounds
underwhelming honestly
fullness rather than nausea
lost 8lb over 1 months on the combination and i genuinely cannot apportion it
🤝6
titrating dead slow
thats the phase 3 one
monotherapy question, did appetite move for you without a GLP-1 alongside
anyone dosing this on a different day to their tirzepatide
monotherapy here
does the fullness effect fade the way appetite suppression does
📈7🤝1
held at 2.5 for 7 months on monotherapy before i touched it again
i titrated over twice as many weeks as i did on semaglutide and that was right for me
*that should say weekly
is anyone running this on its own or is it all CagriSema in here
❤️1
is the combination just the two dosed together or a single formulation
combination for me
follow up did the combination change your GI compared to the GLP-1 alone
two VendorInvestigate results on the same SSA lot came back 96.8 and 99, closer than i expected
👀8
separate days
📈1👀2
update on the earlier thing is the nausea profile genuinely different or am i imagining it
slower than the others
Verification log updated: MKM — evidence added, status unchanged.
😂2
how many weeks before you noticed anything on monotherapy
❤️4💀1📉10
cagrisema thats it
weekly for me, same day every week, no reason beyond habit
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
is the slower titration because of nausea or something else
anyone stopped the GLP-1 and kept only this
held at 0.25 for 5 months on monotherapy before i touched it again
whats the recon people use, 30 in 3ml
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
dropped the GLP-1 and stayed on this alone for 15 months, appetite held but weight barely moved
📈1😂2👀3