anyone dosing this on a different day to their tirzepatide
#cagrilintide 2026-05-22
Friday30 messages9 participantstimes are UTC
Highlights from this day
- triple_ag_tom — two Medutest results on the same SGN lot came back 99.4 and 99, closer than i expected 20:42
- area_percent — the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair 21:26
- chaser_chris — 5 in 2.5ml gives 2.5mg/ml which is what i use, purely because the units come out round 22:26
- yyz_vial — whats REDEFINE testing exactly 22:44
- VialBot — New independent result logged — MKM, lot SG-1177, purity 98.1% (PeptideMeter). 22:47
REDEFINE is the trial
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
two Medutest results on the same SGN lot came back 99.4 and 99, closer than i expected
amylin analogue, so its not a GLP-1 at all right
weekly for me, same day every week, no reason beyond habit
held at 12 for 2 months on monotherapy before i touched it again
how many weeks before you noticed anything on monotherapy
dosing them on different days made no difference i could detect
is the nausea profile genuinely different or am i imagining it
£240 for a 5 vial and it lasts me longer than the GLP-1 does at my doses
combination GI was worse than either alone for me, which is not what i had read anywhere
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
monotherapy here
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
slower than the others
added it to an existing cagrilintide dose rather than starting both, which made attribution possible, ill dig out the number
[edited]cant separate them
i was sceptical about monotherapy and after 12 months im still sceptical, just less so
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
amylin not glp-1
the fullness effect hasnt faded over 15 months, unlike my semaglutide appetite curve
thats the phase 3 one
5 in 2.5ml gives 2.5mg/ml which is what i use, purely because the units come out round
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whats REDEFINE testing exactly
transit-times.csv
181 rows · not retained in the public archive
New independent result logged — MKM, lot SG-1177, purity 98.1% (PeptideMeter).
Archive lookup: triple_ag_tom first appears in this channel on 2025-09-06.
i keep the two on separate days so if something goes wrong i have a chance of knowing which