is the weekly schedule the same here
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#cagrilintide 2025-05-05
Monday21 messages4 participantstimes are UTC
Highlights from this day
- swirl_not_shake — i keep the two on separate days so if something goes wrong i have a chance of knowing which, i could be wrong 21:41
- half_life_hal — the slower titration in here is community habit as much as anything, the trials had their own schedule 21:53
- half_life_hal — follow up the fullness thing is the part people describe differently, food stops being interesting rather than repellent 21:56
combination for me
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
combination GI was worse than either alone for me, which is not what i had read anywhere, your mileage will differ
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
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underwhelming honestly
REDEFINE is the trial
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lost 95lb over 22 months on the combination and i genuinely cannot apportion it
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
fullness rather than nausea
slightly off topic but did anyone find monotherapy underwhelming
weekly for me, same day every week, no reason beyond habit
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dosing them on different days made no difference i could detect
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weekly for me, same day every week, no reason beyond habit, ymmv
dropped the GLP-1 and stayed on this alone for 12 months, appetite held but weight barely moved
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
the fullness effect hasnt faded over 9 months, unlike my semaglutide appetite curve
[edited]cagrisema thats it
i keep the two on separate days so if something goes wrong i have a chance of knowing which, i could be wrong
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update on the earlier thing noticed something around week 21 on monotherapy, well after i had given up expecting to
the slower titration in here is community habit as much as anything, the trials had their own schedule
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follow up the fullness thing is the part people describe differently, food stops being interesting rather than repellent
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separate days