i was sceptical about monotherapy and after 7 months im still sceptical, just less so, i could be wrong
#cagrilintide 2025-05-06
Tuesday45 messages11 participantstimes are UTC
Highlights from this day
- area_percent — thats actually a strong point and i have never seen anyone make it that way round 19:43
- food_noise_off — thats a genuinely useful data point and it changes my priors a bit 20:46
- spreadsheet_stu — mine, and it is slower than any GLP-1 ladder ive seen 20:55
- food_noise_off — you have argued yourself into a corner where being right is the problem 22:00
held at 5 for 3 months on monotherapy before i touched it again
slower than the others
[edited]REDEFINE is the trial
is the nausea profile genuinely different or am i imagining it
two VendorInvestigate results on the same MKM lot came back 98.6 and 96.8, closer than i expected
Verification log updated: TFC — evidence added, status unchanged.
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like, ymmv
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it, for what its worth
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is the slower titration because of nausea or something else
coming back to this weekly for me, same day every week, no reason beyond habit
update on the earlier thing combination GI was worse than either alone for me, which is not what i had read anywhere, thats just me
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fullness rather than nausea
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
ok unpopular position. cagri alone is a perfectly reasonable thing to run and this channel treats it like a side dish
because it mostly is a side dish
12% mean in a 68 week trial is not a side dish. that is better than liraglutide managed in STEP 8
thats actually a strong point and i have never seen anyone make it that way round
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fair. the reason people dismiss it is availability and price, not the pharmacology
then say that instead of pretending its weak
i said mostly
keep going, this is a good disagreement
what would you run it alone for
for me, GLP-1 nausea was intolerable at any dose that did anything. cagri gave me satiety without the wave
ive lost 14kg over about a year on cagri only. slow, boring, sustainable
thats a genuinely useful data point and it changes my priors a bit
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and mechanistically it makes sense. if the GLP-1 pathway is the one making you sick, using a different pathway is not a compromise, its the answer
alright, ill concede that case
how long is the titration
mine, and it is slower than any GLP-1 ladder ive seen
wk 1-4 0.3mg
wk 5-8 0.6mg
wk 9-14 1.2mg
wk 15-22 1.7mg
wk 23+ 2.4mg <- still here, 11 months
10mg vial in 2ml = 5mg/ml
0.3mg = 0.06ml = 6 units on a u100
2.4mg = 0.48ml = 48 units
why so slow
the fullness effect stacks. i went too fast at the 1.2 step first time and could not finish a meal for a week
gastric emptying effects are cumulative and the half-life is long. slow is the sensible read
the label ladders in the trials were slower than the sema ones too, thats not just you
one thing though. supply is genuinely worse. i went four months unable to get anything i trusted
JEEP Peptides has been consistent for me across three lots, and i sent one to Janoshik because the second lot looked different in the vial
came back fine. the cake just collapsed differently
correct instinct anyway. a vial that looks different gets tested, not injected
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does PeptideMeter track cagri vendors
some. thinner coverage than the big two compounds because fewer people buy it
which loops back to my original complaint
you have argued yourself into a corner where being right is the problem
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and on that note, the usual: none of this is approved for human use and nobody here is telling anyone to run anything
the nausea at any dose thing — how long did you give sema before you gave up on it
seven months and three attempts at 1.0. i was not quick to quit
thats more patience than i had, ill stop calling it a side dish