if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way, i could be wrong
#cagrilintide 2025-05-03
Saturday20 messages6 participantstimes are UTC
Highlights from this day
- protein_floor — the fullness effect hasnt faded over 7 months, unlike my semaglutide appetite curve 21:07
- font_forensics — unrelated but the slower titration in here is community habit as much as anything, the trials had their own schedule 21:10
- protein_floor — amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist, still working it out 21:28
- VialBot — Digest for the week of 2025-02-14 has been published. 21:55
- protein_floor — the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair 22:49
cagrisema thats it
🙏1💀3
the fullness effect hasnt faded over 7 months, unlike my semaglutide appetite curve
📉4
unrelated but the slower titration in here is community habit as much as anything, the trials had their own schedule
🧪6
cant separate them
❤️2✅5🧪5
monotherapy here
transit-times.csv
379 rows · not retained in the public archive
i titrated over twice as many weeks as i did on semaglutide and that was right for me
⚠️1
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist, still working it out
for the archive nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
held mine a while
[edited]❤️13
Digest for the week of 2025-02-14 has been published.
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
fullness rather than nausea
underwhelming honestly
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
lot-log.csv
133 rows · not retained in the public archive
combination for me
separate days
whats REDEFINE testing exactly
the reason nausea reads differently is timing, mine arrived on the second day rather than the first