i was sceptical about monotherapy and after 10 months im still sceptical, just less so, ask me again in a month
#cagrilintide 2025-05-02
Friday29 messages9 participantstimes are UTC
Highlights from this day
- logrotate — is anyone running this on its own or is it all CagriSema in here added it to an existing tirzepatide dose rather than starting both, which made attribution possible 22:38
- egfr_ed — 40 in 2.5ml gives 4mg/ml which is what i use, purely because the units come out round 22:42
- redefine_ren — the fullness thing is the part people describe differently, food stops being interesting rather than repellent 22:52
- VialBot — Verification log updated: BCH — evidence added, status unchanged. 23:10
is anyone running this on its own or is it all CagriSema in here
added it to an existing tirzepatide dose rather than starting both, which made attribution possible
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amylin analogue, so its not a GLP-1 at all right
held at 2.5 for 5 months on monotherapy before i touched it again
40 in 2.5ml gives 4mg/ml which is what i use, purely because the units come out round
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anyone stopped the GLP-1 and kept only this
monotherapy was underwhelming for me and i say that as someone who wanted it to work
separate days
is there a reason people titrate this over more weeks than the others
REDEFINE is the trial
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the fullness thing is the part people describe differently, food stops being interesting rather than repellent
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monotherapy did work for me, just slower and smaller than i expected
two Medutest results on the same Homopeptide lot came back 99.4 and 98.1, closer than i expected
weekly for me, same day every week, no reason beyond habit
i keep the two on separate days so if something goes wrong i have a chance of knowing which
slightly off topic but added it to an existing retatrutide dose rather than starting both, which made attribution possible
noticed something around week 3 on monotherapy, well after i had given up expecting to
Verification log updated: BCH — evidence added, status unchanged.
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
back after 15 months, is monotherapy still a minority thing here
fullness rather than nausea
did anyone find monotherapy underwhelming
the nausea felt different rather than less, more fullness and less of the queasy wave
lost 95lb over 19 months on the combination and i genuinely cannot apportion it
while im here the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
thats the phase 3 one
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its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
stopped for 4 months and the fullness went within a fortnight of the last dose
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
amylin not glp-1