the sweet spot argument is really about effect per side effect, not a magic number
i sat at 7.5 for 6 months and never needed more, which is where the folklore comes from
#tirzepatide 2025-05-23
Friday37 messages9 participantstimes are UTC
Highlights from this day
*Medutest not the other one
does the appetite effect feel different or just stronger
i argued the sweet spot was nonsense and then spent 2 months at 7.5 not needing more
coming back to this is the 5 vial the common one or do people use 30
transit-times.csv
180 rows · not retained in the public archive
7.5 gang
🙏2💀13👀1
the 20 vial in 5ml gives 10mg/ml which puts 2 on 30 units, nice round numbers
start low anyway
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
20:28quiet.hours pinned a message to this channel
whats the plateau pattern here, same as semaglutide or different
40 units of a 10 solution is a lot of volume and i check that one twice every single time
whats the top licensed dose, 15 or does it go higher
the 2.5 to 5 step was the roughest one for me and everything after was easier
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
Testing queue: 2 submissions open, 59 awaiting dispatch.
🙏1❤️14
held 10 for 5 months and lost 28kg over that stretch, slow and boring and fine
no gap when i switched, took the last semaglutide dose and started this a week later
is the sweet spot argument about effect or about side effects
10 was enough
15 is the top
👀8✅8🔥13
ok so is SURMOUNT-OSA the sleep apnoea one
easier gi for me
5 was where i first noticed it properly, 2.5 did almost nothing for me, take that with a pinch of salt
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
same plateau here
21:49quiet.hours pinned a message to this channel
how did people handle the 2.5 to 5 jump
plateaued at 19 weeks the same way i did on semaglutide, so i doubt its compound specific
🎉13🧪6💀1
folklore probably
❤️7⚠️8🧪17
i sat at 7.5 for 23 months and never needed more, which is where the folklore comes from
£120 for a 40 vial is roughly what ive paid for the last year
[edited]switched last year
ok so the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
i went to 15 and came back to 10, more suppression wasnt more useful for me, we shall see
❤️1
GIP plus GLP-1