start low anyway
📈13🔥1😂5
#tirzepatide 2025-05-21
Wednesday20 messages4 participantstimes are UTC
Highlights from this day
- two_four_ceiling — does the appetite effect feel different or just stronger 23:27
- two_four_ceiling — SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up 23:40
- two_four_ceiling — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 23:44
at 15 the GI came back for me, so my easier profile claim only applies below that
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, i think
whats the plateau pattern here, same as semaglutide or different
the 2.5 to 5 step was the roughest one for me and everything after was easier
no gap when i switched, took the last semaglutide dose and started this a week later
5 did nothing
if youre coming off semaglutide the honest answer is start low and find out, theres no table, we shall see
GIP plus GLP-1
i went to 15 and came back to 10, more suppression wasnt more useful for me
does the appetite effect feel different or just stronger
⚠️5
ok so why does everyone talk about 7.5 and not 10
how many weeks at 7.5 before you knew it was enough
easier gi for me
coming off semaglutide, is there a conversion or do i restart at 2.5
whats the top licensed dose, 15 or does it go higher
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
£185 for a 20 vial is roughly what ive paid for the last year
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
🎉16
switched last year