vialroom

#tirzepatide 2025-02-07

Friday20 messages5 participantstimes are UTC
Highlights from this day
  • verify_or_dont — anyone tracked whether the GI difference held at the top doses 16:10
  • verify_or_dont — my VendorInvestigate result on a BCH vial came in at 96.8 which is why i keep buying from them 16:13
  • quiet.hours — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, we shall see 18:15
  • residual_solvent — held 10 for 26 months and lost 11kg over that stretch, slow and boring and fine 18:17

the trials titrated every four weeks to a target, most people here stop at whatever works

is 7.5 really the sweet spot or is that just channel folklore

sorry to jump in at 0.25 my appetite is gone entirely, did anyone go down rather than up

NW

5 was where i first noticed it properly, 2.5 did almost nothing for me

went back to semaglutide after 11 months because the cost difference mattered more than the GI

RS

there is no clean conversion between the two, anyone giving you a ratio is guessing

VO

anyone tracked whether the GI difference held at the top doses

Cited study
Tirzepatide for Obstructive Sleep Apnea and Obesity (SURMOUNT-OSA)
New England Journal of Medicine · 2024
AHI as the primary endpoint, with and without PAP therapy.

my VendorInvestigate result on a BCH vial came in at 96.8 which is why i keep buying from them

🙏14
RS

held 10 for 26 months and lost 11kg over that stretch, slow and boring and fine

👀11🙏16📈8

changed my mind about needing 15, i was chasing a number rather than an outcome