at 15 the GI came back for me, so my easier profile claim only applies below that
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#tirzepatide 2025-02-01
Saturday33 messages9 participantstimes are UTC
Highlights from this day
- cold_chain_cmdr — did anyone go past 15 and was there any point to it 16:09
- VialBot — Assay note: WWB lot B-0329 reported at 99% of label content. 17:06
- cold_chain_cmdr — my Medutest result on a BCH vial came in at 99.4 which is why i keep buying from them, ymmv 17:42
- early_satiety — is there a reason to titrate slower than the four week schedule 17:52
restarted at 2.5 after 1 months off and the first two doses reminded me why titration exists
no gap when i switched, took the last semaglutide dose and started this a week later
the 2.5 to 5 step was the roughest one for me and everything after was easier, someone check my working
quick one 5 was where i first noticed it properly, 2.5 did almost nothing for me
held 10 for 26 months and lost 10kg over that stretch, slow and boring and fine
the two compounds arent interchangeable week for week even if the effect ends up similar
same plateau here
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did anyone go past 15 and was there any point to it
[edited]| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
SURMOUNT is weight
switched last year
there is no clean conversion between the two, anyone giving you a ratio is guessing
the 2 vial in 0.5ml gives 2.5mg/ml which puts 0.25 on 25 units, nice round numbers
titrate slow
back after 7 months, do i restart at 2.5 or pick up near where i left off
15 is the top
medutest-report-g-0641.pdf
3 pages · 539 KB · not retained in the public archive
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anyone tracked whether the GI difference held at the top doses
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
easier gi for me
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i log everything and my appetite curve looks flatter across the week than my semaglutide log did, someone check my working
Assay note: WWB lot B-0329 reported at 99% of label content.
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does switching from semaglutide need a gap or do you just start
GIP plus GLP-1
the switch felt like a step down at first and then caught up around week 7
my Medutest result on a BCH vial came in at 99.4 which is why i keep buying from them, ymmv
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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i sat at 7.5 for 20 months and never needed more, which is where the folklore comes from, not advice obviously
did anybody switch back to semaglutide after trying this
is there a reason to titrate slower than the four week schedule
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no clean conversion
coming back to this how many weeks at 7.5 before you knew it was enough
right so went back to semaglutide after 12 months because the cost difference mattered more than the GI
10 was enough
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)5 did nothing
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