is the sweet spot argument about effect or about side effects
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#tirzepatide 2024-10-15
Tuesday32 messages6 participantstimes are UTC
Highlights from this day
- slow.taper — the sweet spot argument is really about effect per side effect, not a magic number 18:00
- salt_bridge — at 15 the GI came back for me, so my easier profile claim only applies below that, still working it out 18:42
- gip_glp_gil — went back to semaglutide after 9 months because the cost difference mattered more than the GI 18:53
if youre coming off semaglutide the honest answer is start low and find out, theres no table
anyone tracked whether the GI difference held at the top doses
does switching from semaglutide need a gap or do you just start
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did going from 2 semaglutide to 5 of this feel like a step down for anyone
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
is SURMOUNT-OSA the sleep apnoea one
the sweet spot argument is really about effect per side effect, not a magic number
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im at 2.5 and thinking about 1.7, did anyone gain anything from that step
unrelated but i log everything and my appetite curve looks flatter across the week than my semaglutide log did
15 is the top
anyone stopped at 10 and stayed there for months
at 15 the GI came back for me, so my easier profile claim only applies below that, still working it out
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
40 units of a 10 solution is a lot of volume and i check that one twice every single time
why does everyone talk about 7.5 and not 10
i argued the sweet spot was nonsense and then spent 17 months at 7.5 not needing more
how many weeks at 7.5 before you knew it was enough
there is no clean conversion between the two, anyone giving you a ratio is guessing
went back to semaglutide after 9 months because the cost difference mattered more than the GI
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€94 for a 40 vial is roughly what ive paid for the last year
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did anybody switch back to semaglutide after trying this
whats the top licensed dose, 15 or does it go higher
i argued the sweet spot was nonsense and then spent 19 months at 7.5 not needing more
restarted at 2.5 after 22 months off and the first two doses reminded me why titration exists, i have it written down somewhere
the switch felt like a step down at first and then caught up around week 30
changed my mind about needing 15, i was chasing a number rather than an outcome
easier gi for me
does the GIP arm actually explain the easier nausea or is that hand waving
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the switch felt like a step down at first and then caught up around week 30, ymmv
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
the GI difference held for me right up to 15, which isnt what a couple of people here found
the sweet spot thing is survivorship, the people it worked for stayed and said so
update on the earlier thing 12 did nothing extra over 10 for me and that still holds a year later
is the 5 vial the common one or do people use 20