there is no clean conversion between the two, anyone giving you a ratio is guessing
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#tirzepatide 2024-10-13
Sunday41 messages11 participantstimes are UTC
Highlights from this day
- mag_citrate — there is no clean conversion between the two, anyone giving you a ratio is guessing 17:42
- blank_slate_bo — the sweet spot argument is really about effect per side effect, not a magic number 18:30
- blank_slate_bo — at 15 the GI came back for me, so my easier profile claim only applies below that 18:59
- dose_day_drift — is SURMOUNT-OSA the sleep apnoea one 19:16
- dose_day_drift — how many weeks at 7.5 before you knew it was enough 19:56
5 did nothing
$120 for a 5 vial is roughly what ive paid for the last year
*Medutest not the other one
Reminder set. I will post here in 2 days.
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slightly off topic but the 15 vial in 1.5ml gives 2mg/ml which puts 2 on 40 units, nice round numbers
anyone tracked whether the GI difference held at the top doses
SURMOUNT is weight
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the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, for what its worth
40 units of a 2.5 solution is a lot of volume and i check that one twice every single time
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
the sweet spot argument is really about effect per side effect, not a magic number
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
does the appetite effect feel different or just stronger
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
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10 was enough
start low anyway
restarted at 2.5 after 10 months off and the first two doses reminded me why titration exists, i have it written down somewhere
[edited]at 15 the GI came back for me, so my easier profile claim only applies below that
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the switch felt like a step down at first and then caught up around week 2
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
same plateau here
no gap when i switched, took the last semaglutide dose and started this a week later, not advice obviously
if youre coming off semaglutide the honest answer is start low and find out, theres no table
switched last year
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
*that should say weekly
how many weeks at 7.5 before you knew it was enough
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the trials titrated every four weeks to a target, most people here stop at whatever works
5 was where i first noticed it properly, 2.5 did almost nothing for me
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no clean conversion
plateaued at 2 weeks the same way i did on semaglutide, so i doubt its compound specific
for the archive why does everyone talk about 7.5 and not 10
for the archive how did people handle the 2.5 to 5 jump
changed my mind about needing 15, i was chasing a number rather than an outcome
GIP plus GLP-1
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
titrate slow
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folklore probably
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right so i log everything and my appetite curve looks flatter across the week than my semaglutide log did
at 15 my appetite went completely and i dropped back a step, eating nothing isnt a win, i could be wrong
switched from 10 semaglutide and started at 2.5, took the slow route, never regretted it
whats the top licensed dose, 15 or does it go higher