is 7.5 really the sweet spot or is that just channel folklore
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#tirzepatide 2024-05-15
Wednesday27 messages8 participantstimes are UTC
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- vialkeeper — is 7.5 really the sweet spot or is that just channel folklore 10:32
- gradient_greg — the trials titrated every four weeks to a target, most people here stop at whatever works, i have it written down somewhere 11:28
- coa_or_cope — 5 was where i first noticed it properly, 2.5 did almost nothing for me, ill dig out the number 11:29
- noct.titrate — at 15 the GI came back for me, so my easier profile claim only applies below that SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its… 13:32
- cold_chain_cmdr — how long before the dual thing was noticeable to you the sweet spot argument is really about effect per side effect, not a magic number 13:40
Reminder set. I will post here in 5 days.
im at 2 and thinking about 12, did anyone gain anything from that step
SURMOUNT is weight
5 did nothing
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i sat at 7.5 for 13 months and never needed more, which is where the folklore comes from, thats one data point
GIP plus GLP-1
anyone tracked whether the GI difference held at the top doses
the switch felt like a step down at first and then caught up around week 24
easier gi for me
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)🎉16😂1
the trials titrated every four weeks to a target, most people here stop at whatever works, i have it written down somewhere
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5 was where i first noticed it properly, 2.5 did almost nothing for me, ill dig out the number
lot-log.csv
735 rows · not retained in the public archive
the two compounds arent interchangeable week for week even if the effect ends up similar
is the sweet spot argument about effect or about side effects
how did people handle the 2.5 to 5 jump
is the 20 vial the common one or do people use 30
follow up the GI difference held for me right up to 15, which isnt what a couple of people here found
why does everyone talk about 7.5 and not 10
the sweet spot argument is really about effect per side effect, not a magic number, anyway
did anybody switch back to semaglutide after trying this
at 15 the GI came back for me, so my easier profile claim only applies below that
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
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the sweet spot thing is survivorship, the people it worked for stayed and said so
no clean conversion
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SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
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how long before the dual thing was noticeable to you
the sweet spot argument is really about effect per side effect, not a magic number
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there is no clean conversion between the two, anyone giving you a ratio is guessing
cold_chain_cmdrhow long before the dual thing was noticeable to you the sweet spot argument is really…
sorry to jump in went back to semaglutide after 15 months because the cost difference mattered more than the GI