cold pack arrived completely liquid, does that mean anything
#storage-coldchain 2025-02-16
Sunday40 messages10 participantstimes are UTC
Highlights from this day
- endotoxin_ed — light exposure matters much less than temperature for these. i still keep them in the carton 19:56
- travel_cooler — unrelated but unopened and in-use in the same place is fine. just keep the in-use one where you can reach it 20:38
- cold_pack_carla — the vial that visibly changed after a warm transit was the one that had already been reconstituted, take that with a pinch of salt 21:26
- VialBot — Reminder for travel_cooler: dose day is today. Set 6 days ago. 21:27
a few hours at room temperature is almost certainly nothing. a week is a different conversation
two to eight
flying with vials, hand luggage or checked
anyone had a vial visibly change after a warm transit
update on the earlier thing a liquid cold pack tells you it was above freezing, not that your vial cooked, thats just me
freeze debate again
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while im here i log the fridge temperature daily and the room has never let me forget it
update on the earlier thing nobody here can tell you a vial is safe. we can tell you what has and has not survived for us
i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine
not the door
right so lyophilised powder is genuinely robust. a warm transit is far less likely to matter than people fear
hotel minibars are frequently not cold enough. i take a thermometer, which is ridiculous and also correct
light exposure matters much less than temperature for these. i still keep them in the carton
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i freeze aliquots and have had them test fine afterwards. others here would not do it and i understand why, n of 1 obviously
light exposure matters much less than temperature for these. i still keep them in the carton
ok so anyone tested a vial before and after a bad transit
reconstituted solution is the fragile part. that is where the cold chain actually earns its keep
power cut with the door shut for a few hours is fine. a full fridge holds temperature surprisingly well
i would bin it
freeze thaw cycling is the risk, not one freeze. that is my read of it anyway, from memory
i have never had a lyophilised vial fail after a warm transit and i have had some bad ones
a cooler with two gel packs held under eight degrees for eleven hours on a drive
unrelated but unopened and in-use in the same place is fine. just keep the in-use one where you can reach it
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a cooler with two gel packs held under eight degrees for eleven hours on a drive
update from 7 months ago: replaced the fridge, temperature is stable, no more anxiety
log it
buy a thermometer
thats fine
*that should say weekly
the practical risk in winter shipping is freezing, and in summer it is heat. plan for the season you are in
do you log the fridge temperature or is that too far
the door swings four or five degrees every time somebody opens it. the back barely moves
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update from 17 months ago: replaced the fridge, temperature is stable, no more anxiety
the vial that visibly changed after a warm transit was the one that had already been reconstituted, take that with a pinch of salt
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Reminder for travel_cooler: dose day is today. Set 6 days ago.
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right so two to eight degrees. most domestic fridge doors are not in that range and people do not check
unrelated but for flying, hand luggage every time. the hold is not temperature controlled the way people assume
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follow up back of the fridge, i have it written down somewhere
if you are worried after a bad transit, test it. that is what the testing channels are for
i would use it
not the freezer
buy a thermometer. mine reads 3.1 on the door and two degrees lower at the back