i have never had a lyophilised vial fail after a warm transit and i have had some bad ones
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#storage-coldchain 2024-09-22
Sunday14 messages4 participantstimes are UTC
Highlights from this day
- reta_resting_hr — i have never had a lyophilised vial fail after a warm transit and i have had some bad ones 11:17
- truncation_tru — two to eight degrees. most domestic fridge doors are not in that range and people do not check, take that with a pinch of salt the practical risk in winter shipping… 11:25
- truncation_tru — unrelated but nobody here can tell you a vial is safe. we can tell you what has and has not survived for us 12:08
- slow.taper — a few hours at room temperature is almost certainly nothing. a week is a different conversation 13:38
- slow.taper — lyophilised powder is genuinely robust. a warm transit is far less likely to matter than people fear 13:50
for the archive freeze thaw cycling is the risk, not one freeze. that is my read of it anyway
two to eight degrees. most domestic fridge doors are not in that range and people do not check, take that with a pinch of salt
the practical risk in winter shipping is freezing, and in summer it is heat. plan for the season you are in
hand luggage
do you keep the unopened vials and the in-use one in the same place
unrelated but nobody here can tell you a vial is safe. we can tell you what has and has not survived for us
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powder is robust
for the archive do you log the fridge temperature or is that too far
freeze debate again
a few hours at room temperature is almost certainly nothing. a week is a different conversation
i log the fridge temperature daily and the room has never let me forget it
my fridge is 5.6
lyophilised powder is genuinely robust. a warm transit is far less likely to matter than people fear