how do you keep it cold on a long drive in summer
#storage-coldchain 2024-09-01
Sunday28 messages6 participantstimes are UTC
Highlights from this day
- customs_owl — a cooler with two gel packs held under eight degrees for eleven hours on a drive 16:55
- group_buy_gwen — lyophilised powder is genuinely robust. a warm transit is far less likely to matter than people fear 18:08
- first_and_last_four — the vial that visibly changed after a warm transit was the one that had already been reconstituted 20:47
how cold is too cold, can it actually freeze in a normal fridge
powder is robust
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a cooler with two gel packs held under eight degrees for eleven hours on a drive
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update on the earlier thing anyone tested a vial before and after a bad transit
do i need to worry about light exposure or is that overthinking
two to eight degrees. most domestic fridge doors are not in that range and people do not check, your mileage will differ
buy a thermometer
reconstituted solution is the fragile part. that is where the cold chain actually earns its keep
if you are worried after a bad transit, test it. that is what the testing channels are for
for flying, hand luggage every time. the hold is not temperature controlled the way people assume
[edited]i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine, i could be wrong
buy a thermometer. mine reads 3.1 on the door and two degrees lower at the back
lyophilised powder is genuinely robust. a warm transit is far less likely to matter than people fear
mon 4.1 / door 7.2
tue 4.0 / door 7.8
wed 4.2 / door 6.9
thu 3.9 / door 7.4
fri 4.1 / door 8.1 <- shopping day
sat 4.3 / door 7.0
sun 4.0 / door 6.8i log the fridge temperature daily and the room has never let me forget it, not advice obviously
back of the fridge
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nobody here can tell you a vial is safe. we can tell you what has and has not survived for us
not the door
i freeze aliquots and have had them test fine afterwards. others here would not do it and i understand why
what temperature does a domestic fridge door actually swing to
the practical risk in winter shipping is freezing, and in summer it is heat. plan for the season you are in
unopened and in-use in the same place is fine. just keep the in-use one where you can reach it
a few hours at room temperature is almost certainly nothing. a week is a different conversation
power cut with the door shut for a few hours is fine. a full fridge holds temperature surprisingly well
the vial that visibly changed after a warm transit was the one that had already been reconstituted
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do you keep the unopened vials and the in-use one in the same place
i have never had a lyophilised vial fail after a warm transit and i have had some bad ones
for the archive hotel minibars are frequently not cold enough. i take a thermometer, which is ridiculous and also correct
power cut for 9 hours, fridge stayed shut, am i fine
unopened and in-use in the same place is fine. just keep the in-use one where you can reach it