genuine question, at what point does this stop being tolerable and start being a reason to stop
#side-effects 2025-08-12
Tuesday49 messages12 participantstimes are UTC
Highlights from this day
- cold_chain_cmdr — depends whether it is trending better week on week. if week 3 is worse than week 2 at the same dose, that is worth acting on 20:39
- ms_ms_mira — for context this is not a surprise finding, it was the headline tolerability story in the registration trial 20:40
- cold_chain_cmdr — that is the single biggest advantage we have and people throw it away by rushing 20:57
- cold_chain_cmdr — textbook. that is what escalation is for 23:31
the sulphur burps seem to track fatty meals for a lot of people here, including me
has anyone had reflux specifically get worse rather than better
it does stop
[edited]quick one right upper side pain on and off for a week, should i be worried
weights-monthly.csv
107 rows · not retained in the public archive
drop a rung
nausea is usually worst somewhere in the first 24 to 72 hours after the dose and then eases
right so magnesium citrate worked for me where oxide did nothing. that might just be absorption, happy to be corrected
thats not a chat question
taste changes settled for me around week eight and never fully came back
*week 6 not week 9
ginger did nothing for me and worked for two other people here. thats where the evidence is at
water first
how long did it take for the GI stuff to actually settle for you
please get seen
dont push through
that settles
day 2 after my shot and i feel like i am on a boat
day 2 is the peak for most people. call it 24 to 72 hours
mine is worst overnight on night two and gone by the friday
the shape of a week, roughly
| Time after dose | What most people report |
|---|---|
| 0-12 h | nothing much, maybe a bit of fullness |
| 24-72 h | worst of the nausea, reflux, early satiety |
| 3-4 days | settling, appetite still low |
| 5-7 days | near baseline, hunger creeping back |
📌11✅4
so this is expected
expected, not compulsory. plenty of people never get it at all
it is a motility effect. gastric emptying slows, and if you put a big fatty meal on top of that you feel every bit of it
meal size was the entire fix for me. i eat about half what i used to per sitting
i have been eating normally and then regretting it
so stop doing that
😄6
small, low fat, slowly, for the first three days. it is boring and it works
should i drop back a dose
depends whether it is trending better week on week. if week 3 is worse than week 2 at the same dose, that is worth acting on
for context this is not a surprise finding, it was the headline tolerability story in the registration trial
how many people dropped out of that for GI
a small minority discontinued for adverse events. most of them rode it out through escalation
and the trials escalate on a fixed schedule because they have to. we do not have to
that is the single biggest advantage we have and people throw it away by rushing
🎯8
i held 0.5 for nine weeks and lost the same as the people who ran straight to 1.7
really
for me, yes. #dosing-titration is full of that argument, it does not settle
response is not linear in dose for everyone, and trial means hide an enormous amount of spread
ok i am holding
good
ginger, cold water, and not lying down after eating. that is my whole toolkit
peppermint tea did nothing for me. ginger did
week 5 update, the day 2 thing is basically gone
cold_chain_cmdrdepends whether it is trending better week on week. if week 3 is worse than week 2 at…
and you never went up, right
held 0.25 for four weeks then moved to 0.5. nausea only on the first shot of the new dose
textbook. that is what escalation is for
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the first shot at any new level is the one to plan around. i inject friday so saturday can be a write-off
stealing that