#semaglutide 2026-06-17

2.4 is the ceiling

restarted after 15 months off at a low dose and the nausea arrived exactly like the first time

ok so steady state is the bit people skip, judging a new dose after eight days tells you almost nothing

FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure

SELECT wasnt weight

the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing

lost about 45kg on the low doses before i even got to 1, which surprised me

held at 1.7 and lost 76lb over 12 months, slower than the trials and fine by me

the long half life flattens the trough more than people expect, i never felt a day seven dip

STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping

did anyone titrate slower than four weeks a step and how did that go

how many weeks before you noticed anything at 7.5

i dont think the plateau is a dose problem most of the time, but i cant prove that

same dose day