how did people handle the jump from 1 to 1.7
#semaglutide 2026-06-16
Tuesday46 messages12 participantstimes are UTC
Highlights from this day
- motivation_gone — while im here changed my mind on the four week rule, i think it depends entirely on how the current dose feels steady state is the bit people skip, judging a new dose… 18:57
- juno_joins — half life is about a week so youre roughly four to five weeks to steady state on any new dose 19:05
- VialBot — Archive lookup: halifax_hplc first appears in this channel on 2025-11-18. 19:24
- halifax_hplc — what did SELECT actually measure, i see it quoted for everything 20:34
- motivation_gone — is there a reason to hold at 1.7 rather than going to 2.4 20:59
the long half life flattens the trough more than people expect, i never felt a day seven dip, ill dig out the number
does the seven day half life mean the last two days are weaker
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
[edited]plateaus move
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
im 12 months in at 7.5 and the appetite effect faded, is that a thing
while im here changed my mind on the four week rule, i think it depends entirely on how the current dose feels
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
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five week steps worked better for me than four, purely on how the second week felt
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
how long did the first 28kg take for people at the low doses
im at 5 and stuck, did anyone break a plateau without going up
half life is about a week so youre roughly four to five weeks to steady state on any new dose
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the plateau hit me at 24 weeks and moved again about a month later without a dose change
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
Archive lookup: halifax_hplc first appears in this channel on 2025-11-18.
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
slower worked better
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lost about 6kg on the low doses before i even got to 1, which surprised me
SELECT wasnt weight
STEP is several trials, so saying STEP said x is usually wrong without a number after it
does moving my dose day by two days matter with a seven day half life
£185 a month for compounded against what brand costs locally is why most people here use vials
does anyone actually run a five week step instead of four
is 2.4 the top or do people go past it
what did SELECT actually measure, i see it quoted for everything
fridge-temps.csv
525 rows · not retained in the public archive
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did anyone titrate slower than four weeks a step and how did that go
held there too
ok so the appetite effect faded for me around 23 months and going up fixed it for a while
i stayed on 1.7 for 11 months and never went to 2.4, appetite was already where i needed it
how many weeks before you noticed anything at 0.5
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
11 months at 2.4 and the honest summary is diminishing returns after the first half
give it four weeks
whats the actual licensed ceiling, i keep seeing different numbers
*VendorInvestigate not the other one
is there a reason to hold at 1.7 rather than going to 2.4
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thats STEP 1
moving my dose day by a day or two never did anything noticeable for me, n of 1 obviously
right so if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
ok so my dose day drifted from friday to sunday, does that reset anything
my 40 vial in 2.5ml gives 2.5mg/ml so 10 lands on 5 units, thats why i picked that volume
restarted after 1 months off at a low dose and the nausea arrived exactly like the first time
*Janoshik not the other one