im 17 months in at 5 and the appetite effect faded, is that a thing
#semaglutide 2026-05-10
Sunday31 messages7 participantstimes are UTC
Highlights from this day
- maintenance_mo — going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution FLOW was the kidney outcomes trial and it gets quoted in here for… 18:56
- maintenance_mo — held at 7.5 and lost 57lb over 1 months, slower than the trials and fine by me 19:11
- vial_ledger — changed my mind on the four week rule, i think it depends entirely on how the current dose feels 20:36
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
held there too
slower worked better
moving my dose day by a day or two never did anything noticeable for me
did the STEP 4 withdrawal arm show what i think it showed
compounded and brand felt the same to me at 1.7, which is one person and nothing more
medutest-report-h-2814.pdf
3 pages · 553 KB · not retained in the public archive
vials not pens here
not the same trial
the appetite effect faded for me around 12 months and going up fixed it for a while, i could be wrong
coming back to this lost about 33kg on the low doses before i even got to 1, which surprised me
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
transit-times.csv
824 rows · not retained in the public archive
held at 7.5 and lost 57lb over 1 months, slower than the trials and fine by me
[edited]wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mghalf life is about a week so youre roughly four to five weeks to steady state on any new dose
how long till steady state, ive read the half life is about a week
the long half life flattens the trough more than people expect, i never felt a day seven dip
STEP 1 ran to 68 weeks. thats the one everyone half remembers
give it four weeks
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
seven days ish
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mghow long did the first 40kg take for people at the low doses
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was STEP 1 the one that ran to 68 weeks or am i mixing them up
mine faded too
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if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
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restarted after 18 months off at a low dose and the nausea arrived exactly like the first time
the plateau hit me at 16 weeks and moved again about a month later without a dose change
13 months at 2.4 and the honest summary is diminishing returns after the first half
follow up vial units and pen clicks are different systems, mixing the two is how people end up wrong
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
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went too fast once
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changed my mind on the four week rule, i think it depends entirely on how the current dose feels
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg📈6📉4