the plateau hit me at 5 weeks and moved again about a month later without a dose change
#semaglutide 2026-05-09
Saturday51 messages9 participantstimes are UTC
Highlights from this day
- non_scale_win — vial units and pen clicks are different systems, mixing the two is how people end up wrong 15:45
- snac_and_water — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 16:50
- seoul_swirl — right so what did SELECT actually measure, i see it quoted for everything 17:11
- surpass_two — my dose day drifted from friday to sunday, does that reset anything 18:21
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
follow up is there a reason to hold at 1.7 rather than going to 2.4
does moving my dose day by two days matter with a seven day half life
lost about 16kg on the low doses before i even got to 1, which surprised me
vials not pens here
sorry to jump in dose day is sunday for me only because thats when i remember, not because sunday matters
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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Digest for the week of 2025-10-18 has been published.
how long till steady state, ive read the half life is about a week
is 2.4 the top or do people go past it
im 11 months in at 12 and the appetite effect faded, is that a thing
i dont think the plateau is a dose problem most of the time, but i cant prove that
moving my dose day by a day or two never did anything noticeable for me
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
five week steps worked better for me than four, purely on how the second week felt
STEP is several trials, so saying STEP said x is usually wrong without a number after it, someone check my working
im at 10 and stuck, did anyone break a plateau without going up
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steady state takes weeks
€72 a month for compounded against what brand costs locally is why most people here use vials
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seven days ish
does anyone actually run a five week step instead of four
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
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coming back to this compounded and brand felt the same to me at 10, which is one person and nothing more
i stayed on 1.7 for 11 months and never went to 2.4, appetite was already where i needed it
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thats STEP 1
is the plateau usually appetite coming back or just the scale stopping
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, n of 1 obviously
right so what did SELECT actually measure, i see it quoted for everything
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follow up the appetite effect faded for me around 18 months and going up fixed it for a while
the long half life flattens the trough more than people expect, i never felt a day seven dip, thats one data point
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
plateaus move
Batch lookup KP-0925: 6 independent reports on file, earliest 2026-03-19.
did anybody find a difference between Homopeptide and pharmacy at the same 2.5
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how did people handle the jump from 1 to 1.7
my dose day drifted from friday to sunday, does that reset anything
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SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, thats one data point
my Medutest report on the WXT vial came back 97.4 against a certificate saying 96.8
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4 months at 2.4 and the honest summary is diminishing returns after the first half
brand vs compounded, is there a difference people can actually feel
SELECT wasnt weight, not advice obviously
slower worked better
same dose day
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
STEP 1 ran to 68 weeks. thats the one everyone half remembers
how many weeks before you noticed anything at 15
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
half life is about a week so youre roughly four to five weeks to steady state on any new dose
2.4 is the ceiling
follow up mine faded too