is 2.4 the top or do people go past it
#semaglutide 2026-04-18
Saturday82 messages14 participantstimes are UTC
Highlights from this day
- tokyo_taper — what did SELECT actually measure, i see it quoted for everything 20:39
- bpc_sceptic — quick one im at 2.4 and stuck, did anyone break a plateau without going up 21:18
- bpc_sceptic — if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 22:09
- bpc_sceptic — is the plateau usually appetite coming back or just the scale stopping vial units and pen clicks are different systems, mixing the two is how people end up wrong 22:16
- nine_nine_one — unrelated but compounded and brand felt the same to me at 10, which is one person and nothing more 22:58
whats the actual licensed ceiling, i keep seeing different numbers
is there a reason to hold at 1.7 rather than going to 2.4
did anyone titrate slower than four weeks a step and how did that go
give it four weeks
[edited]seven days ish
was SELECT the one that ran to 68 weeks or am i mixing them up
anyone gone from 2 straight to 0.25 or is that too big a jump
how long till steady state, ive read the half life is about a week
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my dose day drifted from friday to sunday, does that reset anything
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
slightly off topic but is the plateau at 23 weeks normal or am i doing something wrong
2.4 is the ceiling
dose day is sunday for me only because thats when i remember, not because sunday matters
my 30 vial in 1ml gives 8mg/ml so 10 lands on 5 units, thats why i picked that volume
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does anyone actually run a five week step instead of four
did anyone hold at 7.5 longer than four weeks before going up
brand vs compounded, is there a difference people can actually feel
slower worked better
plateaus move
i stayed on 1.7 for 24 months and never went to 2.4, appetite was already where i needed it
what did SELECT actually measure, i see it quoted for everything
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same dose day
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem, anyway
*Medutest not the other one
Channel stats, last 30 days: 54 messages from 22 members.
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held at 0.5 and lost 34lb over 24 months, slower than the trials and fine by me
did anybody find a difference between WXT and pharmacy at the same 5
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
im 15 months in at 7.5 and the appetite effect faded, is that a thing
how many weeks before you noticed anything at 2.5
went too fast once
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STEP is several trials, so saying STEP said x is usually wrong without a number after it
[edited]Reminder set. I will post here in 2 days.
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
coming back to this FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
auckland_aliquotlicensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
does the seven day half life mean the last two days are weaker
€120 a month for compounded against what brand costs locally is why most people here use vials
quick one im at 2.4 and stuck, did anyone break a plateau without going up
[edited]| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
five week steps worked better for me than four, purely on how the second week felt
unrelated but how did people handle the jump from 1 to 1.7
while im here lost about 6kg on the low doses before i even got to 1, which surprised me
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, take that with a pinch of salt
slightly off topic but 24 months at 2.4 and the honest summary is diminishing returns after the first half
i dont think the plateau is a dose problem most of the time, but i cant prove that
vials not pens here
i held at 2.5 for 4 months and it was the best decision i made
anyone compared their 8 vial dosing against the pen increments
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does moving my dose day by two days matter with a seven day half life
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
held there too
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went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, someone check my working
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did the STEP 4 withdrawal arm show what i think it showed
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgback after 25 months off, do i restart at 0.25 or somewhere higher
SELECT wasnt weight
thats STEP 1
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
moving my dose day by a day or two never did anything noticeable for me
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
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my VendorInvestigate report on the WWB vial came back 99.2 against a certificate saying 98.6
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
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changed my mind on the four week rule, i think it depends entirely on how the current dose feels, happy to be corrected
mine faded too
is the plateau usually appetite coming back or just the scale stopping
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
the appetite effect faded for me around 24 months and going up fixed it for a while
STEP 1 ran to 68 weeks. thats the one everyone half remembers, ill dig out the number
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the plateau hit me at 12 weeks and moved again about a month later without a dose change
*Medutest not the other one
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
*Medutest not the other one
the long half life flattens the trough more than people expect, i never felt a day seven dip
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not the same trial
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
half life is about a week so youre roughly four to five weeks to steady state on any new dose
held there too
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the plateau hit me at 5 weeks and moved again about a month later without a dose change
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unrelated but compounded and brand felt the same to me at 10, which is one person and nothing more
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does the licensed ceiling for weight differ from the diabetes one
same dose day
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steady state takes weeks
vials not pens here
held there too
vial units and pen clicks are different systems, mixing the two is how people end up wrong