restarted after 4 months off at a low dose and the nausea arrived exactly like the first time
#semaglutide 2026-04-17
Friday16 messages5 participantstimes are UTC
Highlights from this day
- stack_sceptic — SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial 11:38
- stack_sceptic — lost about 38kg on the low doses before i even got to 1, which surprised me 11:50
- sharps_comedy — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 11:52
unrelated but did anybody find a difference between CPC and pharmacy at the same 2
£240 a month for compounded against what brand costs locally is why most people here use vials
how did people handle the jump from 1 to 1.7
my 2 vial in 2ml gives 2.5mg/ml so 2 lands on 40 units, thats why i picked that volume
*mg/ml, obviously
the long half life flattens the trough more than people expect, i never felt a day seven dip
give it four weeks
back after 23 months off, do i restart at 0.25 or somewhere higher
my dose day drifted from friday to sunday, does that reset anything
the appetite effect faded for me around 4 months and going up fixed it for a while
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
⚠️17
did anyone hold at 2.5 longer than four weeks before going up
🧊11
lost about 38kg on the low doses before i even got to 1, which surprised me
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
[edited]🧪4👀12
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
for the archive the plateau hit me at 22 weeks and moved again about a month later without a dose change
[edited]