my dose day drifted from friday to sunday, does that reset anything
#semaglutide 2026-04-09
Thursday38 messages9 participantstimes are UTC
Highlights from this day
- declared_value — going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution 19:42
- redefine_ren — SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial 20:29
- declared_value — went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down 20:57
slower worked better
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anyone gone from 1.7 straight to 2.4 or is that too big a jump
vials not pens here
whats the actual licensed ceiling, i keep seeing different numbers
how many weeks before you noticed anything at 10
while im here is there a reason to hold at 1.7 rather than going to 2.4
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
thats STEP 1
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
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does the licensed ceiling for weight differ from the diabetes one
how did people handle the jump from 1 to 1.7
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
*Janoshik not the other one
not the same trial
vial-sg-1177-front.png
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does moving my dose day by two days matter with a seven day half life
is the plateau at 4 weeks normal or am i doing something wrong
SELECT wasnt weight
i dont think the plateau is a dose problem most of the time, but i cant prove that
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did anyone titrate slower than four weeks a step and how did that go
$72 a month for compounded against what brand costs locally is why most people here use vials
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update on the earlier thing i held at 2.5 for 6 months and it was the best decision i made
brand vs compounded, is there a difference people can actually feel
Testing queue: 7 submissions open, 50 awaiting dispatch.
compounded and brand felt the same to me at 2.5, which is one person and nothing more
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
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the long half life flattens the trough more than people expect, i never felt a day seven dip, thats one data point
im at 0.25 and stuck, did anyone break a plateau without going up
New independent result logged — ERP, lot G-0641, purity 97.4% (PeptideMeter).
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
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went too fast once
[edited]SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
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how long till steady state, ive read the half life is about a week
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
restarted after 1 months off at a low dose and the nausea arrived exactly like the first time
steady state takes weeks
the appetite effect faded for me around 24 months and going up fixed it for a while
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step