does moving my dose day by two days matter with a seven day half life
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#semaglutide 2026-04-02
Thursday65 messages12 participantstimes are UTC
Highlights from this day
- a1c_lag — does moving my dose day by two days matter with a seven day half life 16:03
- electrolyte_eli — quick one brand vs compounded, is there a difference people can actually feel 16:51
- two_lifts_a_week — vial units and pen clicks are different systems, mixing the two is how people end up wrong 19:08
- electrolyte_eli — i dont think the plateau is a dose problem most of the time, but i cant prove that 20:01
my PeptideMeter report on the MKM vial came back 99.4 against a certificate saying 98.6
i held at 7.5 for 5 months and it was the best decision i made
*Janoshik not the other one
how long did the first 40kg take for people at the low doses
i held at 12 for 8 months and it was the best decision i made
is the plateau at 7 weeks normal or am i doing something wrong
dose day is sunday for me only because thats when i remember, not because sunday matters
2.4 is the ceiling
did anyone titrate slower than four weeks a step and how did that go
vials not pens here
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my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
held there too
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
janoshik-b-0114.pdf
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compounded and brand felt the same to me at 1.7, which is one person and nothing more
[edited]thats STEP 1
my dose day drifted from friday to sunday, does that reset anything
what did SELECT actually measure, i see it quoted for everything
quick one brand vs compounded, is there a difference people can actually feel
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slower worked better
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moving my dose day by a day or two never did anything noticeable for me
is 2.4 the top or do people go past it
plateaus move
does anyone actually run a five week step instead of four
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
five week steps worked better for me than four, purely on how the second week felt
restarted after 5 months off at a low dose and the nausea arrived exactly like the first time
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went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
ok so back after 5 months off, do i restart at 0.25 or somewhere higher
i dont think the plateau is a dose problem most of the time, but i cant prove that
anyone gone from 12 straight to 0.5 or is that too big a jump
is the plateau usually appetite coming back or just the scale stopping
my 40 vial in 2.5ml gives 5mg/ml so 2.5 lands on 10 units, thats why i picked that volume
did anyone hold at 2 longer than four weeks before going up
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgdoes the licensed ceiling for weight differ from the diabetes one
the long half life flattens the trough more than people expect, i never felt a day seven dip
did anybody find a difference between Homopeptide and pharmacy at the same 15
does the seven day half life mean the last two days are weaker
was SURPASS-2 the one that ran to 68 weeks or am i mixing them up
seven days ish
STEP is several trials, so saying STEP said x is usually wrong without a number after it
steady state takes weeks
how many weeks before you noticed anything at 1
mine faded too
same dose day
[edited]whats the actual licensed ceiling, i keep seeing different numbers
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
went too fast once
not the same trial
half life is about a week so youre roughly four to five weeks to steady state on any new dose
vial units and pen clicks are different systems, mixing the two is how people end up wrong
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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im 26 months in at 1.7 and the appetite effect faded, is that a thing
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
the appetite effect faded for me around 25 months and going up fixed it for a while, happy to be corrected
SELECT wasnt weight
lost about 28kg on the low doses before i even got to 1, which surprised me
did the STEP 4 withdrawal arm show what i think it showed
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
i stayed on 1.7 for 10 months and never went to 2.4, appetite was already where i needed it
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgSTEP 1 ran to 68 weeks. thats the one everyone half remembers
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, thats one data point
the plateau hit me at 10 weeks and moved again about a month later without a dose change
i dont think the plateau is a dose problem most of the time, but i cant prove that
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg👍14
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
STEP 1 ran to 68 weeks. thats the one everyone half remembers