went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
#semaglutide 2026-03-23
Monday55 messages9 participantstimes are UTC
Highlights from this day
- lot_number_lou — brand vs compounded, is there a difference people can actually feel 13:17
- vacuum_vic — was STEP 1 the one that ran to 68 weeks or am i mixing them up 16:37
- belfast_bac — £38 a month for compounded against what brand costs locally is why most people here use vials 17:11
- evidence_or_not — STEP 1 ran to 68 weeks. thats the one everyone half remembers 18:54
how long did the first 42kg take for people at the low doses
STEP is several trials, so saying STEP said x is usually wrong without a number after it, n of 1 obviously
thats STEP 1
did anyone titrate slower than four weeks a step and how did that go
[edited]coming back to this the plateau hit me at 4 weeks and moved again about a month later without a dose change
anyone compared their 10 vial dosing against the pen increments
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
held there too
restarted after 23 months off at a low dose and the nausea arrived exactly like the first time
steady state takes weeks
seven days ish
plateaus move
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
slightly off topic but steady state is the bit people skip, judging a new dose after eight days tells you almost nothing, thats just me
🧪2
same dose day
went too fast once
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
slightly off topic but anyone gone from 2 straight to 7.5 or is that too big a jump
🙏5
held at 10 and lost 11lb over 14 months, slower than the trials and fine by me, take that with a pinch of salt
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
slower worked better
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgSTEP 1 ran to 68 weeks. thats the one everyone half remembers
brand vs compounded, is there a difference people can actually feel
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
SELECT wasnt weight
👀4
mine faded too
2.4 is the ceiling
🙏7😂1
vials not pens here
did anybody find a difference between QST and pharmacy at the same 0.25
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
*Medutest not the other one
my dose day drifted from friday to sunday, does that reset anything
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
im 2 months in at 7.5 and the appetite effect faded, is that a thing
compounded and brand felt the same to me at 0.5, which is one person and nothing more
update on the earlier thing im at 10 and stuck, did anyone break a plateau without going up
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
moving my dose day by a day or two never did anything noticeable for me
give it four weeks
my Janoshik report on the JEEP vial came back 99.2 against a certificate saying 99.4
the appetite effect faded for me around 26 months and going up fixed it for a while
⚠️1
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
📉3🔥1😂1
was STEP 1 the one that ran to 68 weeks or am i mixing them up
🙏15✅6📈1
£38 a month for compounded against what brand costs locally is why most people here use vials
💀17❤️16📉6
3 months at 2.4 and the honest summary is diminishing returns after the first half
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
i stayed on 1.7 for 16 months and never went to 2.4, appetite was already where i needed it
is 2.4 the top or do people go past it
right so my 30 vial in 1ml gives 10mg/ml so 1 lands on 10 units, thats why i picked that volume
STEP 1 ran to 68 weeks. thats the one everyone half remembers
⚠️17💀16
the long half life flattens the trough more than people expect, i never felt a day seven dip
update on the earlier thing dose day is sunday for me only because thats when i remember, not because sunday matters
unrelated but i dont think the plateau is a dose problem most of the time, but i cant prove that
🤝7🎉6
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
coming back to this give it four weeks