the plateau hit me at 33 weeks and moved again about a month later without a dose change, we shall see
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#semaglutide 2026-03-22
Sunday52 messages10 participantstimes are UTC
Highlights from this day
- cold_chain_cmdr — the plateau hit me at 33 weeks and moved again about a month later without a dose change, we shall see 10:49
- coa_or_cope — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 12:38
- per_mg_pete — vial units and pen clicks are different systems, mixing the two is how people end up wrong 13:19
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
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the appetite effect faded for me around 9 months and going up fixed it for a while
[edited]i held at 2.5 for 9 months and it was the best decision i made
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
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held there too
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SELECT wasnt weight
give it four weeks
[edited]im at 15 and stuck, did anyone break a plateau without going up
did anybody find a difference between SSA and pharmacy at the same 1
compounded and brand felt the same to me at 1, which is one person and nothing more
[edited]five week steps worked better for me than four, purely on how the second week felt
i dont think the plateau is a dose problem most of the time, but i cant prove that, your mileage will differ
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
[edited]STEP is several trials, so saying STEP said x is usually wrong without a number after it, i could be wrong
went too fast once
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
how did people handle the jump from 1 to 1.7
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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€72 a month for compounded against what brand costs locally is why most people here use vials
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
slower worked better
for the archive whats the actual licensed ceiling, i keep seeing different numbers
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how long till steady state, ive read the half life is about a week
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does anyone actually run a five week step instead of four
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, still working it out
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
lost about 42kg on the low doses before i even got to 1, which surprised me
did the STEP 4 withdrawal arm show what i think it showed
same dose day
while im here how long did the first 44kg take for people at the low doses
not the same trial
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seven days ish
[edited]if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
brand vs compounded, is there a difference people can actually feel
slightly off topic but dose day is sunday for me only because thats when i remember, not because sunday matters
thats STEP 1
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
janoshik-c-4402.pdf
2 pages · 158 KB · not retained in the public archive
my Janoshik report on the ERP vial came back 98.1 against a certificate saying 99.2
does the licensed ceiling for weight differ from the diabetes one
steady state takes weeks
is there a reason to hold at 1.7 rather than going to 2.4
5 months at 2.4 and the honest summary is diminishing returns after the first half
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, ymmv
restarted after 26 months off at a low dose and the nausea arrived exactly like the first time
my 15 vial in 3ml gives 2mg/ml so 10 lands on 20 units, thats why i picked that volume
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moving my dose day by a day or two never did anything noticeable for me
2.4 is the ceiling
*PeptideMeter not the other one
i stayed on 1.7 for 2 months and never went to 2.4, appetite was already where i needed it
while im here anyone gone from 7.5 straight to 2.5 or is that too big a jump
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