sorry to jump in vial units and pen clicks are different systems, mixing the two is how people end up wrong
#semaglutide 2026-02-12
Thursday47 messages10 participantstimes are UTC
Highlights from this day
- gip_glp_gil — steady state is the bit people skip, judging a new dose after eight days tells you almost nothing 14:33
- fake_tracking — i dont think the plateau is a dose problem most of the time, but i cant prove that 15:20
- ari_arrives — half life is about a week so youre roughly four to five weeks to steady state on any new dose 18:30
for the archive the appetite effect faded for me around 22 months and going up fixed it for a while, ill dig out the number
steady state takes weeks
genuine question anyone compared their 4 vial dosing against the pen increments
$240 a month for compounded against what brand costs locally is why most people here use vials
plateaus move
dose day is sunday for me only because thats when i remember, not because sunday matters, from memory
thats STEP 1
my 10 vial in 0.5ml gives 10mg/ml so 10 lands on 10 units, thats why i picked that volume
[edited]STEP is several trials, so saying STEP said x is usually wrong without a number after it
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgif youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
is there a reason to hold at 1.7 rather than going to 2.4
moving my dose day by a day or two never did anything noticeable for me
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went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
went too fast once
did anybody find a difference between ERP and pharmacy at the same 2.5
i dont think the plateau is a dose problem most of the time, but i cant prove that
📈10🔥8
held at 0.5 and lost 68lb over 7 months, slower than the trials and fine by me
slower worked better
❤️3
lost about 13kg on the low doses before i even got to 1, which surprised me
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
what did SELECT actually measure, i see it quoted for everything
i held at 2.4 for 2 months and it was the best decision i made
10 months at 2.4 and the honest summary is diminishing returns after the first half
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
seven days ish
Digest for the week of 2026-01-04 has been published.
im at 1 and stuck, did anyone break a plateau without going up
give it four weeks
*week 22 not week 9
STEP 1 ran to 68 weeks. thats the one everyone half remembers
how did people handle the jump from 1 to 1.7
[edited]follow up the plateau hit me at 13 weeks and moved again about a month later without a dose change
same dose day
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
the long half life flattens the trough more than people expect, i never felt a day seven dip
not the same trial
held there too
half life is about a week so youre roughly four to five weeks to steady state on any new dose
📉4❤️15🧊15
did anyone titrate slower than four weeks a step and how did that go
mine faded too
does the seven day half life mean the last two days are weaker
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, ymmv
was STEP 1 the one that ran to 68 weeks or am i mixing them up
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genuine question how many weeks before you noticed anything at 15
i stayed on 1.7 for 13 months and never went to 2.4, appetite was already where i needed it, i have it written down somewhere