right so lost about 11kg on the low doses before i even got to 1, which surprised me
#semaglutide 2026-02-04
Wednesday44 messages8 participantstimes are UTC
Highlights from this day
- wick_weighs — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, your mileage will differ 18:07
- protein_floor — brand vs compounded, is there a difference people can actually feel 18:46
- taipei_tare — the plateau hit me at 9 weeks and moved again about a month later without a dose change 19:30
- taipei_tare — dose day is sunday for me only because thats when i remember, not because sunday matters 19:39
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
[edited]did the STEP 4 withdrawal arm show what i think it showed
🧊5
seven days ish
does anyone actually run a five week step instead of four
the appetite effect faded for me around 1 months and going up fixed it for a while
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slightly off topic but FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
mine faded too
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held there too
steady state takes weeks
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
how long till steady state, ive read the half life is about a week
SELECT wasnt weight
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, your mileage will differ
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
while im here went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, ask me again in a month
my PeptideMeter report on the HJ vial came back 98.1 against a certificate saying 96.8
i held at 0.5 for 9 months and it was the best decision i made
right so vial units and pen clicks are different systems, mixing the two is how people end up wrong
went too fast once
is the plateau usually appetite coming back or just the scale stopping
coming back to this the long half life flattens the trough more than people expect, i never felt a day seven dip
thats STEP 1
brand vs compounded, is there a difference people can actually feel
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
restarted after 3 months off at a low dose and the nausea arrived exactly like the first time
is the plateau at 9 weeks normal or am i doing something wrong
does the licensed ceiling for weight differ from the diabetes one
slightly off topic but was STEP 1 the one that ran to 68 weeks or am i mixing them up
compounded and brand felt the same to me at 1.7, which is one person and nothing more
2.4 is the ceiling
anyone gone from 12 straight to 5 or is that too big a jump
held at 1 and lost 73lb over 8 months, slower than the trials and fine by me
€94 a month for compounded against what brand costs locally is why most people here use vials
give it four weeks
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is there a reason to hold at 1.7 rather than going to 2.4
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
[edited]i dont think the plateau is a dose problem most of the time, but i cant prove that
the plateau hit me at 9 weeks and moved again about a month later without a dose change
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im at 5 and stuck, did anyone break a plateau without going up
€94 a month for compounded against what brand costs locally is why most people here use vials
dose day is sunday for me only because thats when i remember, not because sunday matters
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19 months at 2.4 and the honest summary is diminishing returns after the first half
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
slower worked better
vials not pens here