i dont think the plateau is a dose problem most of the time, but i cant prove that
#semaglutide 2026-01-30
Friday48 messages11 participantstimes are UTC
Highlights from this day
- verify_or_dont — my dose day drifted from friday to sunday, does that reset anything 14:06
- reship_rita — is there a reason to hold at 1.7 rather than going to 2.4 16:41
- reship_rita — licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose 17:10
- cold_chain_cmdr — compounded and brand felt the same to me at 1.7, which is one person and nothing more 18:37
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, not advice obviously
STEP 1 ran to 68 weeks. thats the one everyone half remembers
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im at 0.5 and stuck, did anyone break a plateau without going up
what did SELECT actually measure, i see it quoted for everything
my dose day drifted from friday to sunday, does that reset anything
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brand vs compounded, is there a difference people can actually feel
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does moving my dose day by two days matter with a seven day half life
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held there too
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
Recon calculator: 10mg in 1.5ml = 10mg/ml.
the appetite effect faded for me around 17 months and going up fixed it for a while
moving my dose day by a day or two never did anything noticeable for me
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vials not pens here
did anybody find a difference between SWB and pharmacy at the same 7.5
follow up 12 months at 2.4 and the honest summary is diminishing returns after the first half
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
slower worked better
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
i stayed on 1.7 for 14 months and never went to 2.4, appetite was already where i needed it
mine faded too
how did people handle the jump from 1 to 1.7
seven days ish
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anyone gone from 15 straight to 0.25 or is that too big a jump
five week steps worked better for me than four, purely on how the second week felt
did anyone titrate slower than four weeks a step and how did that go
did the STEP 4 withdrawal arm show what i think it showed
held at 15 and lost 97lb over 22 months, slower than the trials and fine by me
i held at 2.4 for 7 months and it was the best decision i made
give it four weeks
half life is about a week so youre roughly four to five weeks to steady state on any new dose
did anyone hold at 0.5 longer than four weeks before going up
SELECT wasnt weight
dose day is sunday for me only because thats when i remember, not because sunday matters
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
is the plateau at 33 weeks normal or am i doing something wrong
is there a reason to hold at 1.7 rather than going to 2.4
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my 15 vial in 1ml gives 4mg/ml so 2 lands on 12 units, thats why i picked that volume
steady state takes weeks
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgthats STEP 1
does the licensed ceiling for weight differ from the diabetes one
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
lost about 36kg on the low doses before i even got to 1, which surprised me
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgcompounded and brand felt the same to me at 1.7, which is one person and nothing more
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