the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
#semaglutide 2026-01-29
Thursday63 messages13 participantstimes are UTC
Highlights from this day
- sharps_bin_sid — dose day is sunday for me only because thats when i remember, not because sunday matters 09:51
- mg_per_ml — quick one the long half life flattens the trough more than people expect, i never felt a day seven dip 12:09
- cricket_or_footy — does the seven day half life mean the last two days are weaker 12:36
- mg_per_ml — dose day is sunday for me only because thats when i remember, not because sunday matters 14:16
- mg_per_ml — STEP 1 ran to 68 weeks. thats the one everyone half remembers 16:37
i held at 5 for 8 months and it was the best decision i made
vial units and pen clicks are different systems, mixing the two is how people end up wrong
thats STEP 1
genuine question the appetite effect faded for me around 23 months and going up fixed it for a while
while im here steady state is the bit people skip, judging a new dose after eight days tells you almost nothing, i have it written down somewhere
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
sharps_bin_sidgenuine question the appetite effect faded for me around 23 months and going up fixed…
brand vs compounded, is there a difference people can actually feel
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
medutest-report-c-4402.pdf
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whats the actual licensed ceiling, i keep seeing different numbers
vials not pens here
dose day is sunday for me only because thats when i remember, not because sunday matters
[edited]| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the plateau hit me at 18 weeks and moved again about a month later without a dose change
went too fast once
[edited]sorry to jump in half life is about a week so youre roughly four to five weeks to steady state on any new dose
compounded and brand felt the same to me at 1.7, which is one person and nothing more
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held at 2 and lost 32lb over 8 months, slower than the trials and fine by me
update on the earlier thing changed my mind on the four week rule, i think it depends entirely on how the current dose feels
did anybody find a difference between GL Biochem and pharmacy at the same 0.25
same dose day
steady state takes weeks
my Janoshik report on the JEEP vial came back 98.1 against a certificate saying 99.2, we shall see
16 months at 2.4 and the honest summary is diminishing returns after the first half
my 10 vial in 3ml gives 8mg/ml so 0.5 lands on 30 units, thats why i picked that volume
restarted after 15 months off at a low dose and the nausea arrived exactly like the first time
plateaus move
what did SELECT actually measure, i see it quoted for everything
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, still working it out
update on the earlier thing licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
was SURPASS-2 the one that ran to 68 weeks or am i mixing them up
coming back to this compounded and brand felt the same to me at 0.5, which is one person and nothing more
is there a reason to hold at 1.7 rather than going to 2.4
STEP is several trials, so saying STEP said x is usually wrong without a number after it
slower worked better
2.4 is the ceiling
[edited]i held at 10 for 3 months and it was the best decision i made
quick one the long half life flattens the trough more than people expect, i never felt a day seven dip
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does the seven day half life mean the last two days are weaker
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while im here €240 a month for compounded against what brand costs locally is why most people here use vials
give it four weeks
held there too
five week steps worked better for me than four, purely on how the second week felt
does moving my dose day by two days matter with a seven day half life
dose day is sunday for me only because thats when i remember, not because sunday matters
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did the STEP 4 withdrawal arm show what i think it showed
SELECT wasnt weight
i dont think the plateau is a dose problem most of the time, but i cant prove that
i stayed on 1.7 for 10 months and never went to 2.4, appetite was already where i needed it
does the licensed ceiling for weight differ from the diabetes one
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STEP is several trials, so saying STEP said x is usually wrong without a number after it
update on the earlier thing moving my dose day by a day or two never did anything noticeable for me
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
quick one anyone compared their 5 vial dosing against the pen increments
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how many weeks before you noticed anything at 2.4
mine faded too
lost about 37kg on the low doses before i even got to 1, which surprised me
compounded and brand felt the same to me at 5, which is one person and nothing more
STEP 1 ran to 68 weeks. thats the one everyone half remembers
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went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
how long did the first 33kg take for people at the low doses
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution