is there a reason to hold at 1.7 rather than going to 2.4
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg🧪7
#semaglutide 2026-01-07
Wednesday31 messages9 participantstimes are UTC
Highlights from this day
- satiety_sig — is there a reason to hold at 1.7 rather than going to 2.4 12:43
- lead_time_lars — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 16:05
- pbs_pip — half life is about a week so youre roughly four to five weeks to steady state on any new dose vial units and pen clicks are different systems, mixing the two is how… 16:20
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
*that should say weekly
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
SELECT wasnt weight
STEP 1 ran to 68 weeks. thats the one everyone half remembers
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moving my dose day by a day or two never did anything noticeable for me, for what its worth
[edited]my 20 vial in 0.5ml gives 4mg/ml so 0.25 lands on 5 units, thats why i picked that volume
lost about 45kg on the low doses before i even got to 1, which surprised me
coming back to this my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
plateaus move
is 2.4 the top or do people go past it
give it four weeks
mine faded too
£55 a month for compounded against what brand costs locally is why most people here use vials, ill dig out the number
went too fast once
ok so my PeptideMeter report on the SWB vial came back 99 against a certificate saying 98.1
same dose day
😂2🙏7📈17
slower worked better
did the STEP 4 withdrawal arm show what i think it showed
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
⚠️14🔥11
half life is about a week so youre roughly four to five weeks to steady state on any new dose
vial units and pen clicks are different systems, mixing the two is how people end up wrong
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the appetite effect faded for me around 22 months and going up fixed it for a while
how long did the first 38kg take for people at the low doses
seven days ish
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg🤝15💀1🎉8
held there too
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgvials not pens here
🧊12📈11
2.4 is the ceiling
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
12 months at 2.4 and the honest summary is diminishing returns after the first half
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
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how long till steady state, ive read the half life is about a week