going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
#semaglutide 2025-12-20
Saturday37 messages7 participantstimes are UTC
Highlights from this day
- ghk_gia — update on the earlier thing lost about 11kg on the low doses before i even got to 1, which surprised me 18:24
- ghk_gia — i dont think the plateau is a dose problem most of the time, but i cant prove that 18:27
- VialBot — Verification log updated: GL Biochem — evidence added, status unchanged. 18:35
- gip_glp_gil — if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, still working it out 19:56
- secretagogue_sy — went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step 20:02
same dose day
the plateau hit me at 19 weeks and moved again about a month later without a dose change
held there too
while im here is the plateau usually appetite coming back or just the scale stopping
was SURMOUNT-1 the one that ran to 68 weeks or am i mixing them up
did anyone hold at 12 longer than four weeks before going up
anyone compared their 10 vial dosing against the pen increments
give it four weeks
genuine question STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
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went too fast once
steady state takes weeks
right so the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing, ymmv
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did anybody find a difference between QYB and pharmacy at the same 2.4
2.4 is the ceiling
update on the earlier thing lost about 11kg on the low doses before i even got to 1, which surprised me
i dont think the plateau is a dose problem most of the time, but i cant prove that
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does the licensed ceiling for weight differ from the diabetes one
*PeptideMeter not the other one
mine faded too
Verification log updated: GL Biochem — evidence added, status unchanged.
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the appetite effect faded for me around 24 months and going up fixed it for a while
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, ymmv
coming back to this is the plateau at 13 weeks normal or am i doing something wrong
my PeptideMeter report on the JEEP vial came back 99.2 against a certificate saying 96.8, someone check my working
does anyone actually run a five week step instead of four
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coming back to this anyone gone from 15 straight to 1.7 or is that too big a jump
is there a reason to hold at 1.7 rather than going to 2.4
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unrelated but restarted after 22 months off at a low dose and the nausea arrived exactly like the first time
thats STEP 1
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, still working it out
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changed my mind on the four week rule, i think it depends entirely on how the current dose feels
plateaus move
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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slower worked better
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whats the actual licensed ceiling, i keep seeing different numbers