restarted after 12 months off at a low dose and the nausea arrived exactly like the first time
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#semaglutide 2025-11-24
Monday63 messages11 participantstimes are UTC
Highlights from this day
- lean_mass_lex — restarted after 12 months off at a low dose and the nausea arrived exactly like the first time 21:44
- third_shift — i held at 2.5 for 7 months and it was the best decision i made 22:45
- third_shift — lost about 35kg on the low doses before i even got to 1, which surprised me 22:50
- abdo_two_inch — my plateau was the scale stopping while appetite stayed suppressed, which is a different problem 23:04
- pharmac_pen — how long did the first 37kg take for people at the low doses 23:10
compounded and brand felt the same to me at 0.5, which is one person and nothing more, n of 1 obviously
steady state takes weeks
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back after 16 months off, do i restart at 0.25 or somewhere higher
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
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slightly off topic but did anyone hold at 0.25 longer than four weeks before going up
does the licensed ceiling for weight differ from the diabetes one
the plateau hit me at 2 weeks and moved again about a month later without a dose change
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SELECT wasnt weight
same dose day
ok so STEP 1 ran to 68 weeks. thats the one everyone half remembers
quick one brand vs compounded, is there a difference people can actually feel
anyone compared their 4 vial dosing against the pen increments
2.4 is the ceiling
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
give it four weeks
how long till steady state, ive read the half life is about a week
appetite_backthe plateau hit me at 2 weeks and moved again about a month later without a dose change
is the plateau usually appetite coming back or just the scale stopping
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
plateaus move
held there too
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
slower worked better
update on the earlier thing five week steps worked better for me than four, purely on how the second week felt
seven days ish
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im 24 months in at 2.5 and the appetite effect faded, is that a thing
thats STEP 1
moving my dose day by a day or two never did anything noticeable for me
STEP is several trials, so saying STEP said x is usually wrong without a number after it
i stayed on 1.7 for 2 months and never went to 2.4, appetite was already where i needed it
is there a reason to hold at 1.7 rather than going to 2.4
coming back to this £120 a month for compounded against what brand costs locally is why most people here use vials, someone check my working
mine faded too
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
i held at 2.5 for 7 months and it was the best decision i made
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while im here did anybody find a difference between WXT and pharmacy at the same 1.7
does moving my dose day by two days matter with a seven day half life
lost about 35kg on the low doses before i even got to 1, which surprised me
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how did people handle the jump from 1 to 1.7
vials not pens here
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the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
the appetite effect faded for me around 9 months and going up fixed it for a while
went too fast once
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
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going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
how long did the first 37kg take for people at the low doses
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
not the same trial
genuine question the long half life flattens the trough more than people expect, i never felt a day seven dip, from memory
steady state takes weeks
my dose day drifted from friday to sunday, does that reset anything
whats the actual licensed ceiling, i keep seeing different numbers
while im here how many weeks before you noticed anything at 1.7
what did SELECT actually measure, i see it quoted for everything
vial units and pen clicks are different systems, mixing the two is how people end up wrong
dose day is sunday for me only because thats when i remember, not because sunday matters
medutest-report-e-2205.pdf
3 pages · 935 KB · not retained in the public archive
seven days ish
half life is about a week so youre roughly four to five weeks to steady state on any new dose
i dont think the plateau is a dose problem most of the time, but i cant prove that
anyone gone from 2.4 straight to 1 or is that too big a jump
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, i have it written down somewhere
my 30 vial in 1.5ml gives 4mg/ml so 0.25 lands on 25 units, thats why i picked that volume
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