half life is about a week so youre roughly four to five weeks to steady state on any new dose
#semaglutide 2025-10-25
Saturday60 messages11 participantstimes are UTC
Highlights from this day
- sharps_bin_sid — is there a reason to hold at 1.7 rather than going to 2.4 19:20
- sharps_bin_sid — ok so did anyone hold at 1 longer than four weeks before going up i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 19:36
- motivation_gone — 5 months at 2.4 and the honest summary is diminishing returns after the first half 19:48
is there a reason to hold at 1.7 rather than going to 2.4
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2.4 is the ceiling
did anybody find a difference between SSA and pharmacy at the same 15
does anyone actually run a five week step instead of four
genuine question the long half life flattens the trough more than people expect, i never felt a day seven dip, i could be wrong
ok so did anyone hold at 1 longer than four weeks before going up
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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while im here my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
right so moving my dose day by a day or two never did anything noticeable for me
5 months at 2.4 and the honest summary is diminishing returns after the first half
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follow up restarted after 8 months off at a low dose and the nausea arrived exactly like the first time
janoshik-d-0718.pdf
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went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
mine faded too
slower worked better
Recon calculator: 20mg in 2.5ml = 8mg/ml.
did anyone titrate slower than four weeks a step and how did that go
went too fast once
my 5 vial in 5ml gives 8mg/ml so 5 lands on 15 units, thats why i picked that volume
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same dose day
right so SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
seven days ish
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
steady state takes weeks
unrelated but STEP is several trials, so saying STEP said x is usually wrong without a number after it, thats just me
*that should say weekly
vials not pens here
i dont think the plateau is a dose problem most of the time, but i cant prove that
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing, someone check my working
$94 a month for compounded against what brand costs locally is why most people here use vials
for the archive vial units and pen clicks are different systems, mixing the two is how people end up wrong
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
STEP 1 ran to 68 weeks. thats the one everyone half remembers
lost about 21kg on the low doses before i even got to 1, which surprised me
SELECT wasnt weight
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
held there too
my Janoshik report on the QSC vial came back 99.4 against a certificate saying 98.6
plateaus move
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five week steps worked better for me than four, purely on how the second week felt
update on the earlier thing whats the actual licensed ceiling, i keep seeing different numbers
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the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
is 2.4 the top or do people go past it
not the same trial
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the appetite effect faded for me around 3 months and going up fixed it for a while
dose day is sunday for me only because thats when i remember, not because sunday matters
brand vs compounded, is there a difference people can actually feel
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steady state takes weeks
the long half life flattens the trough more than people expect, i never felt a day seven dip
give it four weeks
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went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
€55 a month for compounded against what brand costs locally is why most people here use vials
what did SELECT actually measure, i see it quoted for everything
compounded and brand felt the same to me at 2, which is one person and nothing more
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does moving my dose day by two days matter with a seven day half life
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how long till steady state, ive read the half life is about a week
i stayed on 1.7 for 23 months and never went to 2.4, appetite was already where i needed it
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
vial units and pen clicks are different systems, mixing the two is how people end up wrong
£94 a month for compounded against what brand costs locally is why most people here use vials
same dose day
how did people handle the jump from 1 to 1.7
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
im 11 months in at 7.5 and the appetite effect faded, is that a thing