#semaglutide 2025-09-27

Saturday19 messages3 participantstimes are UTC

Highlights from this day

nhs_pathway_nell — coming back to this i stayed on 1.7 for 11 months and never went to 2.4, appetite was already where i needed it, i could be wrong 19:35
nhs_pathway_nell — is there a reason to hold at 1.7 rather than going to 2.4 19:41
drawup_dee — held at 15 and lost 70lb over 2 months, slower than the trials and fine by me 20:07

right so STEP is several trials, so saying STEP said x is usually wrong without a number after it

the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing

the appetite effect faded for me around 2 months and going up fixed it for a while

coming back to this i stayed on 1.7 for 11 months and never went to 2.4, appetite was already where i needed it, i could be wrong

$94 a month for compounded against what brand costs locally is why most people here use vials

the long half life flattens the trough more than people expect, i never felt a day seven dip

my 20 vial in 2.5ml gives 4mg/ml so 5 lands on 5 units, thats why i picked that volume

is there a reason to hold at 1.7 rather than going to 2.4

📈18🤝6🎉6

SELECT wasnt weight

held at 15 and lost 70lb over 2 months, slower than the trials and fine by me

wk 1-4    0.25mg
wk 5-10   0.50mg   (held 2 extra weeks)
wk 11-14  1.00mg
wk 15-26  1.70mg   (held, long)
wk 27+    2.40mg

i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication

*Medutest not the other one

if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule

*PeptideMeter not the other one

my plateau was the scale stopping while appetite stayed suppressed, which is a different problem, from memory

update on the earlier thing does anyone actually run a five week step instead of four

my dose day drifted from friday to sunday, does that reset anything

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial

ok so STEP 1 ran to 68 weeks. thats the one everyone half remembers