restarted after 16 months off at a low dose and the nausea arrived exactly like the first time
#semaglutide 2025-09-25
Thursday15 messages4 participantstimes are UTC
Highlights from this day
- meniscus_mel — the appetite effect faded for me around 20 months and going up fixed it for a while 21:10
- meniscus_mel — STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping 21:14
- meniscus_mel — STEP 1 ran to 68 weeks. thats the one everyone half remembers 21:21
- egfr_ed — the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing 21:49
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
the appetite effect faded for me around 20 months and going up fixed it for a while
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STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
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lost about 4kg on the low doses before i even got to 1, which surprised me
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im 23 months in at 2.5 and the appetite effect faded, is that a thing
slightly off topic but half life is about a week so youre roughly four to five weeks to steady state on any new dose
STEP 1 ran to 68 weeks. thats the one everyone half remembers
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
five week steps worked better for me than four, purely on how the second week felt
my Janoshik report on the SSA vial came back 99.2 against a certificate saying 99
did the STEP 4 withdrawal arm show what i think it showed
did anybody find a difference between HJ and pharmacy at the same 0.25
*Janoshik not the other one
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
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mine faded too