thats STEP 1
#semaglutide 2025-09-20
Saturday45 messages9 participantstimes are UTC
Highlights from this day
- fibre_first — STEP 1 ran to 68 weeks. thats the one everyone half remembers 13:04
- stack_sceptic — does the licensed ceiling for weight differ from the diabetes one 13:36
- maintenance_mo — is the plateau at 13 weeks normal or am i doing something wrong 13:52
- VialBot — New independent result logged — KP, lot A-2601, purity 96.8% (VendorInvestigate). 15:34
the appetite effect faded for me around 21 months and going up fixed it for a while
ok so going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
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STEP 1 ran to 68 weeks. thats the one everyone half remembers
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i held at 5 for 3 months and it was the best decision i made
how long did the first 32kg take for people at the low doses
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
did anyone hold at 7.5 longer than four weeks before going up
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my Janoshik report on the SSA vial came back 98.1 against a certificate saying 98.6
is there a reason to hold at 1.7 rather than going to 2.4
plateaus move
does the licensed ceiling for weight differ from the diabetes one
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
give it four weeks
does anyone actually run a five week step instead of four
is the plateau at 13 weeks normal or am i doing something wrong
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ok so held at 10 and lost 35lb over 24 months, slower than the trials and fine by me
the long half life flattens the trough more than people expect, i never felt a day seven dip
not the same trial
seven days ish
lost about 47kg on the low doses before i even got to 1, which surprised me
restarted after 6 months off at a low dose and the nausea arrived exactly like the first time
held there too
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while im here did anyone titrate slower than four weeks a step and how did that go
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
same dose day
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
mine faded too
five week steps worked better for me than four, purely on how the second week felt
Reminder set. I will post here in 2 days.
quick one is 2.4 the top or do people go past it
moving my dose day by a day or two never did anything noticeable for me
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
for the archive SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
slower worked better
went too fast once
New independent result logged — KP, lot A-2601, purity 96.8% (VendorInvestigate).
vial units and pen clicks are different systems, mixing the two is how people end up wrong
SELECT wasnt weight
$72 a month for compounded against what brand costs locally is why most people here use vials
was SURPASS-2 the one that ran to 68 weeks or am i mixing them up
dose day is sunday for me only because thats when i remember, not because sunday matters
whats the actual licensed ceiling, i keep seeing different numbers
how long till steady state, ive read the half life is about a week
vials not pens here
2.4 is the ceiling
17 months at 2.4 and the honest summary is diminishing returns after the first half, i think
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