steady state takes weeks
#semaglutide 2025-09-03
Wednesday42 messages9 participantstimes are UTC
Highlights from this day
- wrong_network — i dont think the plateau is a dose problem most of the time, but i cant prove that 19:02
- VialBot — Assay note: GL Biochem lot A-2418 reported at 99% of label content. 20:21
- tokyo_taper — how long did the first 46kg take for people at the low doses 20:40
- VialBot — New independent result logged — ERP, lot B-0114, purity 98.6% (VendorInvestigate). 20:45
im 25 months in at 0.5 and the appetite effect faded, is that a thing
what did SELECT actually measure, i see it quoted for everything
give it four weeks
the appetite effect faded for me around 14 months and going up fixed it for a while, thats just me
quick one im at 2.4 and stuck, did anyone break a plateau without going up
moving my dose day by a day or two never did anything noticeable for me
went too fast once
dose day is sunday for me only because thats when i remember, not because sunday matters, your mileage will differ
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing, thats just me
SELECT wasnt weight
is the plateau usually appetite coming back or just the scale stopping
i dont think the plateau is a dose problem most of the time, but i cant prove that
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i held at 1.7 for 6 months and it was the best decision i made
seven days ish
held there too
plateaus move
five week steps worked better for me than four, purely on how the second week felt
genuine question my dose day drifted from friday to sunday, does that reset anything
*that should say weekly
right so 5 months at 2.4 and the honest summary is diminishing returns after the first half
how long till steady state, ive read the half life is about a week
2.4 is the ceiling
thats STEP 1
half life is about a week so youre roughly four to five weeks to steady state on any new dose
anyone gone from 2.5 straight to 10 or is that too big a jump
[edited]restarted after 14 months off at a low dose and the nausea arrived exactly like the first time
did the STEP 4 withdrawal arm show what i think it showed
held at 2.4 and lost 30lb over 10 months, slower than the trials and fine by me
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
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right so is 2.4 the top or do people go past it
i stayed on 1.7 for 16 months and never went to 2.4, appetite was already where i needed it
the appetite effect faded for me around 16 months and going up fixed it for a while
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
Assay note: GL Biochem lot A-2418 reported at 99% of label content.
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vials not pens here
20:26ferrous_ash pinned a message to this channel
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
did anyone hold at 2.4 longer than four weeks before going up
how long did the first 46kg take for people at the low doses
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STEP is several trials, so saying STEP said x is usually wrong without a number after it
New independent result logged — ERP, lot B-0114, purity 98.6% (VendorInvestigate).
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my 10 vial in 1ml gives 2.5mg/ml so 5 lands on 40 units, thats why i picked that volume
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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