lost about 32kg on the low doses before i even got to 1, which surprised me
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#semaglutide 2025-08-13
Wednesday32 messages5 participantstimes are UTC
Highlights from this day
- gradient_greg — held at 0.25 and lost 99lb over 21 months, slower than the trials and fine by me, ill dig out the number 06:54
- lean_mass_lex — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 07:55
- sulphur_burp — restarted after 11 months off at a low dose and the nausea arrived exactly like the first time 10:08
follow up dose day is sunday for me only because thats when i remember, not because sunday matters
quick one STEP 1 ran to 68 weeks. thats the one everyone half remembers, i have it written down somewhere
STEP is several trials, so saying STEP said x is usually wrong without a number after it
i dont think the plateau is a dose problem most of the time, but i cant prove that
five week steps worked better for me than four, purely on how the second week felt, we shall see
does the licensed ceiling for weight differ from the diabetes one
*Medutest not the other one
2.4 is the ceiling
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is 2.4 the top or do people go past it
held at 0.25 and lost 99lb over 21 months, slower than the trials and fine by me, ill dig out the number
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quick one STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
[edited]mine faded too
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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vials not pens here
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
is there a reason to hold at 1.7 rather than going to 2.4
quick one the long half life flattens the trough more than people expect, i never felt a day seven dip
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plateaus move
SELECT wasnt weight
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
thats STEP 1
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
half life is about a week so youre roughly four to five weeks to steady state on any new dose
restarted after 11 months off at a low dose and the nausea arrived exactly like the first time
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how did people handle the jump from 1 to 1.7
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
seven days ish