quick one the plateau hit me at 26 weeks and moved again about a month later without a dose change, i could be wrong
#semaglutide 2025-07-20
Sunday27 messages7 participantstimes are UTC
Highlights from this day
- glasgow_vial — steady state is the bit people skip, judging a new dose after eight days tells you almost nothing 14:07
- retention_time — genuine question whats the actual licensed ceiling, i keep seeing different numbers 14:33
- auckland_aliquot — STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, happy to be corrected 14:58
went too fast once
thats STEP 1
is the plateau at 14 weeks normal or am i doing something wrong
vials not pens here
i held at 7.5 for 7 months and it was the best decision i made
SELECT wasnt weight
my dose day drifted from friday to sunday, does that reset anything
the long half life flattens the trough more than people expect, i never felt a day seven dip
give it four weeks
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
6 months at 2.4 and the honest summary is diminishing returns after the first half
five week steps worked better for me than four, purely on how the second week felt
anyone gone from 7.5 straight to 12 or is that too big a jump
*that should say weekly
ok so licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
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14:08quiet.hours pinned a message to this channel
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
[edited]the long half life flattens the trough more than people expect, i never felt a day seven dip, someone check my working
is the plateau usually appetite coming back or just the scale stopping
mine faded too
genuine question whats the actual licensed ceiling, i keep seeing different numbers
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*Medutest not the other one
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
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changed my mind on the four week rule, i think it depends entirely on how the current dose feels
lost about 35kg on the low doses before i even got to 1, which surprised me
did anyone titrate slower than four weeks a step and how did that go
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, happy to be corrected