slower worked better
#semaglutide 2025-07-08
Tuesday31 messages8 participantstimes are UTC
Highlights from this day
- VialBot — Archive lookup: no_escrow_nate first appears in this channel on 2024-10-26. 06:44
- step_one_sian — how did people handle the jump from 1 to 1.7 08:53
- step_one_sian — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, someone check my working 08:55
- secretagogue_sy — the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing 12:07
genuine question how long till steady state, ive read the half life is about a week
Archive lookup: no_escrow_nate first appears in this channel on 2024-10-26.
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vial units and pen clicks are different systems, mixing the two is how people end up wrong
does anyone actually run a five week step instead of four
the plateau hit me at 16 weeks and moved again about a month later without a dose change
STEP 1 ran to 68 weeks. thats the one everyone half remembers
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mine faded too
how did people handle the jump from 1 to 1.7
is the plateau at 14 weeks normal or am i doing something wrong
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, someone check my working
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while im here licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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my VendorInvestigate report on the HJ vial came back 98.6 against a certificate saying 96.8, still working it out
the appetite effect faded for me around 23 months and going up fixed it for a while
restarted after 12 months off at a low dose and the nausea arrived exactly like the first time
did the STEP 4 withdrawal arm show what i think it showed
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
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held at 12 and lost 21lb over 24 months, slower than the trials and fine by me
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, ymmv
sorry to jump in went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
i dont think the plateau is a dose problem most of the time, but i cant prove that
what did SELECT actually measure, i see it quoted for everything
12:03ferrous_ash pinned a message
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgvials not pens here
is 2.4 the top or do people go past it
went too fast once
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
is there a reason to hold at 1.7 rather than going to 2.4
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
moving my dose day by a day or two never did anything noticeable for me