vialroom

#semaglutide 2025-06-28

Saturday46 messages12 participantstimes are UTC
Highlights from this day
  • advance_fee_al — vial units and pen clicks are different systems, mixing the two is how people end up wrong 18:14
  • typosquat_tay — is the plateau at 11 weeks normal or am i doing something wrong 18:15
  • fake_tracking — how many weeks before you noticed anything at 2.5 18:34
  • alt_ast_ali — did anybody find a difference between GGPeps and pharmacy at the same 12 21:43

held at 10 and lost 88lb over 9 months, slower than the trials and fine by me

AF

vial units and pen clicks are different systems, mixing the two is how people end up wrong

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TT

is the plateau at 11 weeks normal or am i doing something wrong

Cited study
Tirzepatide versus Semaglutide Once Weekly in Type 2 Diabetes (SURPASS-2)
New England Journal of Medicine · 2021
The head-to-head everyone quotes. Note the semaglutide comparator dose.
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TT

right so back after 21 months off, do i restart at 0.25 or somewhere higher

going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution

SS

the long half life flattens the trough more than people expect, i never felt a day seven dip

FT

how many weeks before you noticed anything at 2.5

site-rotation-map.png
1000 × 700 · 287 KB · not retained in the public archive
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FT

changed my mind on the four week rule, i think it depends entirely on how the current dose feels

licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose

⚠️2

the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing

seven days ish

AA

FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure

same dose day

SN

dose day is sunday for me only because thats when i remember, not because sunday matters

STEP 1 ran to 68 weeks. thats the one everyone half remembers

AA

i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, ask me again in a month

AA

my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
my 40 vial in 2.5ml gives 4mg/ml so 2 lands on 30 units, thats why i picked that volume

SN

i dont think the plateau is a dose problem most of the time, but i cant prove that
lost about 34kg on the low doses before i even got to 1, which surprised me

$38 a month for compounded against what brand costs locally is why most people here use vials

lost about 26kg on the low doses before i even got to 1, which surprised me

SN

compounded and brand felt the same to me at 1, which is one person and nothing more

SD

half life is about a week so youre roughly four to five weeks to steady state on any new dose

PP

STEP is several trials, so saying STEP said x is usually wrong without a number after it

quick one how long did the first 26kg take for people at the low doses

FD

the plateau hit me at 29 weeks and moved again about a month later without a dose change

coming back to this mine faded too, not advice obviously

for the archive steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
five week steps worked better for me than four, purely on how the second week felt

PP

sorry to jump in is the plateau usually appetite coming back or just the scale stopping

AA

did anybody find a difference between GGPeps and pharmacy at the same 12