i held at 12 for 5 months and it was the best decision i made
#semaglutide 2025-06-22
Sunday58 messages11 participantstimes are UTC
Highlights from this day
- VialBot — Verification log updated: GGPeps — evidence added, status unchanged. 11:39
- tenpence — i dont think the plateau is a dose problem most of the time, but i cant prove that 12:05
- mg_per_ml — €72 a month for compounded against what brand costs locally is why most people here use vials 12:30
- stack_sceptic — the appetite effect faded for me around 4 months and going up fixed it for a while 13:21
- low_and_slow — does the licensed ceiling for weight differ from the diabetes one 16:10
slower worked better
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how long till steady state, ive read the half life is about a week
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
anyone compared their 2 vial dosing against the pen increments
eighteen_monthsthe trials titrated on a fixed schedule, most people here dont, worth remembering when…
is 2.4 the top or do people go past it
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, i could be wrong
Verification log updated: GGPeps — evidence added, status unchanged.
Inter-lab diff for lot SG-1177: 98.6% vs 96.8%. Within expected range.
the plateau hit me at 34 weeks and moved again about a month later without a dose change
lost about 33kg on the low doses before i even got to 1, which surprised me
not the same trial
same dose day
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i dont think the plateau is a dose problem most of the time, but i cant prove that
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my 5 vial in 2ml gives 10mg/ml so 10 lands on 30 units, thats why i picked that volume
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
did anyone titrate slower than four weeks a step and how did that go
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
whats the actual licensed ceiling, i keep seeing different numbers
€72 a month for compounded against what brand costs locally is why most people here use vials
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12:32tenpence pinned a message to this channel
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
Digest for the week of 2024-11-29 has been published.
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
the plateau hit me at 7 weeks and moved again about a month later without a dose change
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
right so my VendorInvestigate report on the GL Biochem vial came back 99 against a certificate saying 99.4
went too fast once
mine faded too
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the appetite effect faded for me around 4 months and going up fixed it for a while
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgunrelated but changed my mind on the four week rule, i think it depends entirely on how the current dose feels
vials not pens here
ok so how long did the first 48kg take for people at the low doses
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
does anyone actually run a five week step instead of four
vial units and pen clicks are different systems, mixing the two is how people end up wrong, take that with a pinch of salt
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back after 13 months off, do i restart at 0.25 or somewhere higher
i stayed on 1.7 for 12 months and never went to 2.4, appetite was already where i needed it
held at 2.4 and lost 36lb over 26 months, slower than the trials and fine by me, still working it out
STEP is several trials, so saying STEP said x is usually wrong without a number after it, ill dig out the number
[edited]SELECT wasnt weight
moving my dose day by a day or two never did anything noticeable for me, anyway
Assay note: MKM lot B-0114 reported at 97.4% of label content.
held there too
does the licensed ceiling for weight differ from the diabetes one
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im at 12 and stuck, did anyone break a plateau without going up
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
STEP 1 ran to 68 weeks. thats the one everyone half remembers
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the long half life flattens the trough more than people expect, i never felt a day seven dip, your mileage will differ
restarted after 17 months off at a low dose and the nausea arrived exactly like the first time
steady state takes weeks
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thats STEP 1
seven days ish
does moving my dose day by two days matter with a seven day half life
give it four weeks
*week 4 not week 3
SELECT wasnt weight