held at 1 and lost 64lb over 11 months, slower than the trials and fine by me
#semaglutide 2025-05-17
Saturday31 messages6 participantstimes are UTC
Highlights from this day
- fasting_insulin — my PeptideMeter report on the MKM vial came back 96.8 against a certificate saying 99.2 18:13
- identity_shift — right so my plateau was the scale stopping while appetite stayed suppressed, which is a different problem 18:48
- cricket_or_footy — back after 18 months off, do i restart at 0.25 or somewhere higher 19:39
- cricket_or_footy — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 20:28
15 months at 2.4 and the honest summary is diminishing returns after the first half
my PeptideMeter report on the MKM vial came back 96.8 against a certificate saying 99.2
lost about 7kg on the low doses before i even got to 1, which surprised me
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
i held at 0.25 for 2 months and it was the best decision i made
compounded and brand felt the same to me at 1.7, which is one person and nothing more
is the plateau usually appetite coming back or just the scale stopping
*Medutest not the other one
right so my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
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moving my dose day by a day or two never did anything noticeable for me
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
how long did the first 44kg take for people at the low doses
i dont think the plateau is a dose problem most of the time, but i cant prove that, not advice obviously
STEP 1 ran to 68 weeks. thats the one everyone half remembers
steady state takes weeks
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
not the same trial
STEP is several trials, so saying STEP said x is usually wrong without a number after it
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
back after 18 months off, do i restart at 0.25 or somewhere higher
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my 30 vial in 1ml gives 2.5mg/ml so 2.4 lands on 25 units, thats why i picked that volume
vial units and pen clicks are different systems, mixing the two is how people end up wrong
held there too
the plateau hit me at 32 weeks and moved again about a month later without a dose change
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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chain_of_custodySELECT was cardiovascular outcomes in people with overweight and existing disease, not…
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, ymmv
vials not pens here
right so i stayed on 1.7 for 7 months and never went to 2.4, appetite was already where i needed it
five week steps worked better for me than four, purely on how the second week felt